The role of cancer-associated fibroblasts in cancer progression and chemotherapy resistance of colorectal cancer

doi:10.3877/cma.j.issn.2095-3224.2023.03.011

Abstract

Abstract:

Colorectal cancer ranks top three on the morbidity and is the second most common cause of cancer death globally. The tumorigenesis of colorectal cancer is closely related to the tumor microenvironment, in which cancer-associated fibroblasts have the capacity of controlling cancer progression. A better understanding of cancer-associated fibroblasts may help us develop new ways of cancer diagnosis, treatment, and prognosis. Herein, we introduce the origin and heterogeneity of cancer-associated fibroblasts, also summarize the role of cancer-associated fibroblasts in colorectal cancer cell proliferation, metastasis, remodeling of extracellular matrix, angiogenesis, tumor immunity, chemotherapy resistance, as well as discussing new advances in targeted therapy.

Key words: Colorectal neoplasms, Cancer-associated fibroblasts, Drug resistance

Paerhati Nadina, Chen Huang. The role of cancer-associated fibroblasts in cancer progression and chemotherapy resistance of colorectal cancer[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2023, 12(03): 241-247.

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References 67

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靶向结直肠癌CAFs	参考文献
FAP	［60］
α-SMA	［19］
TGF-β	［62］
IL1β	［63］
CXCL12	［64］
HGF	［65］
Vitamin D receptor	［66］
NOX4	［67］
CXCR2	［51］

靶向结直肠癌CAFs	参考文献
FAP	［60］
α-SMA	［19］
TGF-β	［62］
IL1β	［63］
CXCL12	［64］
HGF	［65］
Vitamin D receptor	［66］
NOX4	［67］
CXCR2	［51］

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