Research progress of glutathione in proliferation, metastasis and diagnosis and treatment of colorectal cancer

doi:10.3877/cma.j.issn.2095-3224.2022.06.009

Abstract

Abstract:

The morbidity and mortality of colorectal cancer rank second and third in malignancies around the globe, respectively. Glutathione is an important component of the antioxidant system in organisms. Studies in or outside China have shown that glutathione is abnormally increased in colorectal cancer tissues, and is involved in oxidative stress and ferroptosis of colorectal cancer cells, and has the potential to become a therapeutic target of colorectal cancer. In this paper, we have focused mainly on the studies of glutathione in the proliferation, metastasis, diagnosis and treatment of colorectal cancer, and elaborated its research status and application prospects in colorectal cancer.

Key words: Colorectal neoplasms, Glutathione, Oxidative stress, Ferroptosis

Chengfei Liu, Shaoqiang Xu, Tian Yao, He Huang. Research progress of glutathione in proliferation, metastasis and diagnosis and treatment of colorectal cancer[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2022, 11(06): 506-510.

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