The clinical data of 4 cases of multiple primary colorectuml cancer in right colon and rectum from September 2016 to August 2017 were retrospectively analysed. All four patients met the diagnosis criteria for multiple primary colorectuml cancer in right colon and rectum. Three of all participants were synchronous colorectal cancer and another one was metachronous colorectal cancer. Three SCRC patients underwent combined radical surgery in the two parts and left branches in middle colic artery of these three participants were retained in right hemicolectomy. The MCRC patient underwent extend right hemicolectomy at the first time and radical anterior resection at the second time. In addition, no associated postsurgical complication was observed in all three subjects. Among the four patients, 100% survived with a mean follow-up time of 8.75±4.57 months. No transfer and recrudescence were observed in the two SCRC patients. When radical surgery for multiple primary colorectal cancer in right colon and rectum is conducted, it is recommended to retain left colic artery and/or left branches of middle colic artery to ensure the blood supply of descending colon and of left part of transverse colon, and to avoid total celectomy caused by the ischemia of remain colon and avoid the constriction and leakage of intestinal stomas due to the ischemia.