Aspirin in the prophylaxis and treatment of colorectal cancer

doi:10.3877/cma.j.issn.2095-3224.2014.03.02

Abstract

Abstract:

As a fundamental anti-platelet drug, aspirin has been widely administrated in the treatment of cardiovascular diseases.In the past 20 years, with the increasing incidence of colorectal cancer(CRC), there has been great concern on the role of aspirin in the treatment of CRC.Several retrospective clinical trails revealed that CRC patients with regular aspirin intake benefited from higher cancer specific survival and lower incidence of metastasis.Therefore, the question whether aspirin would be an effective anti-CRC drug in the primary prevention and adjuvant therapy, apart from 5-Fu, oxaliplatin, irinotecan and monoclonal antibodies is under intensive discussion.In this review, we aim to summarize recently published clinical trails and try to investigate the role of aspirin in CRC prevention and adjuvant therapy with its limitations for the guidance of clinical practice and future study.

Key words: Aspirin, Colorectal neoplasms, Universal precautions, Neoadjuvant therapy

Nan CHEN, Jin GU, Ming LI. Aspirin in the prophylaxis and treatment of colorectal cancer[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2014, 03(03): 167-171.

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