The correlationship between the level of platelet membrane glycoprotein GPⅡb/Ⅲa and clinical pathological characteristics in colorectal cancer

doi:10.3877/cma.j.issn.2095-3224.2012.02.05

Abstract

Abstract:

Objective

To explore the correlationship between the level of platelet membrane glycoprotein GPⅡb/Ⅲa and clinical pathological characteristics in colorectal cancer(CRC).

Methods

The number of platelets was detected by routine blood test.The level of GPⅡb/Ⅲa was detected by Flow Cytometer.The expression of microvessel density(MVD)in CRC tissue was assessed by Immunohistochemistry.

Results

The number of platelets of CRC patients was significantly higher than that of control group [(251.61±83.71)×10⁹/L vs(184.71±34.48)×10⁹/L, (P<0.05)]. The level of platelet GPⅡb/Ⅲa in CRC patients was significantly higher than that in control group[(25.95±16.92)vs(4.45±2.49), (P<0.05)], and it was correlated with lymph node metastasis [(31.90±17.92)vs(19.34±13.00), (P<0.01)]. The level of platelet GPⅡb/Ⅲa in stage T3-4 was higher than that in stage T1-2[(28.01±17.22)vs(12.95±5.32), (P<0.02)]; and it was correlated with TNM staging(P<0.05).

Conclusion

The level of GPⅡb/Ⅲa may be involved in the development or progression of colorectal cancer.

Key words: Blood platelets, Platelet glycoprotein GPⅡb-Ⅲa complex, Colorectal neoplasms, Microvessel density

Zhong-xin LI, Yi-tao JIA, Rui-chao GENG, Ce ZHOU, Yan GUO, Li-gai GUO. The correlationship between the level of platelet membrane glycoprotein GPⅡb/Ⅲa and clinical pathological characteristics in colorectal cancer[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2012, 01(02): 74-78.

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Figures/Tables 5

References 10

[1]	Jennings LK,shmun RA,Dockter ME, et al.Analysis of human platelet glycoproteins Ⅱb-Ⅲa and Glanzmann's thrombasthenia in whole blood by flow cytometry.Blood, 1986, 68(1): 173-179.
[2]	Weidar N. Intratumor microvessel density as a prognosis factor in cancer.Am J Pathol, 1995, 147(1): 9-19.
[3]	Michelson AD.Flow cytometry：a clinical test of platelet function.Blood, 1996, 87(12): 4925-4936.
[4]	Ringvall M,Thulin A,Zhang L. Enhanced platelet activation mediates the accelerated angiogenic switch in micelacking histidine-rich glycoprotein.PLos One, 2011, 6(1): 1452-1456.
[5]	Engebraaten O,Trikha M,Juell S, et al.Inhibition of in vivo tumour growth by the blocking of host alpha(v)beta3 and alphaⅡ(b)beta3 integrins.Anticancer Res, 2009, 29(1): 131-137.
[6]	Naumov GN,Bender E,Zurakowski D, et al.A model of human tumor dormancy：an angiogenic switch from the nonangiogenic phenotype.J Natl Cancer Inst, 2006, 98(5): 316-325.
[7]	Almog N,Henke V,Flores L, et al.Prolonged dormancy of human liposarcoma is associated with impaired tumor angiogenesis.FASEB, 2006, 20(7): 947-949.
[8]	Soonthornthum T,Suraseraneewong V,Kengsakol K, et al.Thrombocytosis in advanced epithelial ovarian cancer.J Med Assoc Thai, 2007, 90(8): 1495-1500.
[9]	Starnes HB,Patel AA,Stouffer GA.Optimal use of platelet glycoprotein Ⅱb/Ⅲa receptor antagonists in patients ndergoing percutaneous coronary interventions.Drugs, 2011, 71(15): 2009-2030.
[10]	Labelle M,Begum S,Hynes RO.Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal- like transition and promotes metastasis.Cancer Cell, 2011, 20(5): 576-590

临床病理参数		例数	血小板计数(1×10⁹/L)	P值	血小板GPⅡb/Ⅲa的表达水平	P值
年龄(岁)		?	?	0.383	?	0.118
?	>60	36	241.95±97.68	?	22.47±14.44	?
?	≤60	59	257.50±74.20	?	28.12±18.21	?
性别		?	?	0.275	?	0.134
?	男	60	246.08±78.04	?	27.74±19.91	?
?	女	35	266.04±96.34	?	23.05±10.03	?
TNM分期		?	?	0.071	?	0.003
?	Ⅰ	11	218.80±98.77	?	11.94±3.86	?
?	Ⅱ	34	248.34±70.39	?	21.80±14.24	?
?	Ⅲ～Ⅳ	50	261.05±88.17	?	31.90±17.92	?
分化程度		?	?	0.860	?	0.493
?	高～中	72	250.75±84.88	?	25.27±17.73	?
?	低	23	254.31±81.73	?	28.07±14.25	?
CEA(μg/L)		?	?	0.393	?	0.060
?	>5	39	260.45±99.13	?	30.06±19.23	?
?	≤5	56	245.5±71..36	?	23.09±14.62	?
淋巴结转移		?	?	0.249	?	0.007
?	有	50	261.05±88.17	?	31.90±17.92	?
?	无	45	241.12±78.09	?	19.34±13.00	?
浸润深度		?	?	0.132	?	0.022
?	T1-2	13	219.06±90.31	?	12.95±5.32	?
?	T3-4	82	256.77±82.02	?	28.01±17.22	?

临床病理参数		例数	血小板计数(1×10⁹/L)	P值	血小板GPⅡb/Ⅲa的表达水平	P值
年龄(岁)		?	?	0.383	?	0.118
?	>60	36	241.95±97.68	?	22.47±14.44	?
?	≤60	59	257.50±74.20	?	28.12±18.21	?
性别		?	?	0.275	?	0.134
?	男	60	246.08±78.04	?	27.74±19.91	?
?	女	35	266.04±96.34	?	23.05±10.03	?
TNM分期		?	?	0.071	?	0.003
?	Ⅰ	11	218.80±98.77	?	11.94±3.86	?
?	Ⅱ	34	248.34±70.39	?	21.80±14.24	?
?	Ⅲ～Ⅳ	50	261.05±88.17	?	31.90±17.92	?
分化程度		?	?	0.860	?	0.493
?	高～中	72	250.75±84.88	?	25.27±17.73	?
?	低	23	254.31±81.73	?	28.07±14.25	?
CEA(μg/L)		?	?	0.393	?	0.060
?	>5	39	260.45±99.13	?	30.06±19.23	?
?	≤5	56	245.5±71..36	?	23.09±14.62	?
淋巴结转移		?	?	0.249	?	0.007
?	有	50	261.05±88.17	?	31.90±17.92	?
?	无	45	241.12±78.09	?	19.34±13.00	?
浸润深度		?	?	0.132	?	0.022
?	T1-2	13	219.06±90.31	?	12.95±5.32	?
?	T3-4	82	256.77±82.02	?	28.01±17.22	?

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