切换至 "中华医学电子期刊资源库"

中华结直肠疾病电子杂志 ›› 2023, Vol. 12 ›› Issue (02) : 163 -166. doi: 10.3877/cma.j.issn.2095-3224.2023.02.012

综述

结直肠癌肝转移发生机制的研究进展
金玺1, 孙康1,(), 郭建1, 孔梅1,()   
  1. 1. 212001 镇江,江苏大学附属医院胃肠外科
  • 收稿日期:2022-08-10 出版日期:2023-04-25
  • 通信作者: 孙康, 孔梅
  • 基金资助:
    镇江市社会发展项目(SH2019089)

Research progress in the mechanism of colorectal cancer liver metastases

Xi Jin1, Kang Sun1,(), Jian Guo1, Mei Kong1,()   

  1. 1. Department of General Surgery, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China
  • Received:2022-08-10 Published:2023-04-25
  • Corresponding author: Kang Sun, Mei Kong
引用本文:

金玺, 孙康, 郭建, 孔梅. 结直肠癌肝转移发生机制的研究进展[J]. 中华结直肠疾病电子杂志, 2023, 12(02): 163-166.

Xi Jin, Kang Sun, Jian Guo, Mei Kong. Research progress in the mechanism of colorectal cancer liver metastases[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2023, 12(02): 163-166.

结直肠癌是消化道系统最常见的恶性肿瘤之一,随着生活水平的提高呈逐年上升趋势,而结直肠癌肝转移(CRLM)是导致患者死亡的最主要原因之一。目前对于结直肠癌的发生机制尚未完全阐明,因此对CRLM发生机制的深入研究,将有助于对结直肠癌患者的检查、诊断和治疗。本文通过总结国内外相关文献,介绍CRLM的潜在发生机制。

Colorectal cancer (CRC) is one of the most common malignant tumors of the digestive system which is increasing year by year with the improvement of living standard. Colorectal liver metastases(CRLM) is the leading cause of death of patients. The molecular mechanism of colorectal cancer has not been fully elucidated, so the in-depth study of the molecular mechanism of CRLM will be helpful for the examination, diagnosis and treatment of patients with colorectal cancer. This paper summarized the domestic and foreign literature to introduce the current research status of CRLM.

[1]
Feng QY, Wei Y, Chen JW, et al. Anti-EGFR and anti-VEGF agents: important targeted therapies of colorectal liver metastases[J]. World J Gastroenterol, 2014, 20(15): 4263-4275.
[2]
Tang B, Liang W, Liao Y, et al. PEA15 promotes liver metastasis of colorectal cancer by upregulating the ERK/MAPK signaling pathway[J]. Oncol Rep, 2019, 41(1): 43-56.
[3]
Lindgren M, Rask G, Jonsson J, et al. Type IV collagen in human colorectal liver metastases—cellular origin and a circulating biomarker[J]. Cancers, 2022, 14(14): 3396.
[4]
张敏, 冯怡锟, 张岩, 等. 结直肠腺癌组织中MMP2、ADAM17及E-cadherin的表达及临床意义[J]. 癌症进展, 2020, 18(4): 414-417.
[5]
魏双琴, 李迎春, 张成, 等. MMP-7、MMP-9基因多态性与结直肠癌发病的关系研究[J]. 中国现代医学杂志, 2018, 28(2): 42-46.
[6]
Barabás L, Hritz I, István G, et al. The behavior of MMP-2, MMP-7, MMP-9, and their inhibitors TIMP-1 and TIMP-2 in adenoma-colorectal cancer sequence[J]. Dig Dis, 2021, 39(3): 217-224.
[7]
Böckelman C, Beilmann-Lehtonen I, Kaprio T, et al. Serum MMP-8 and TIMP-1 predict prognosis in colorectal cancer[J]. BMC Cancer, 2018, 18(1): 679.
[8]
郑香伟, 陈克河, 康继厚. Ataxin-3和MMP-11在伴肝转移结直肠癌组织中的表达及临床意义[J]. 临床肿瘤学杂志, 2019, 24(5): 401-405.
[9]
Liu J, Xiao Q, Xiao J, et al. Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities[J]. Signal transduction and targeted therapy, 2022, 7(1): 3.
[10]
李炜玉, 黄圆圆, 江志敏, 等. Wnt通路激活的结直肠癌细胞抑制肿瘤浸润性树突细胞成熟的机制研究[J]. 岭南现代临床外科, 2019, 19(2): 162-168.
[11]
Cheng X, Xu X, Chen D, et al. Therapeutic potential of targeting the Wnt/β-catenin signaling pathway in colorectal cancer[J]. Biomedicine & Pharmacotherapy, 2019, 110: 473-481.
[12]
Sun K, He SB, Yao YZ, et al. Tre2 (USP6NL) promotes colorectal cancer cell proliferation via Wnt/β-catenin pathway[J]. Cancer Cell International, 2019, 19: 1-12.
[13]
Tang Q, Chen J, Di Z, et al. TM4SF1 promotes EMT and cancer stemness via the Wnt/β-catenin/SOX2 pathway in colorectal cancer[J]. Journal of Experimental & Clinical Cancer Research, 2020, 39(1): 232.
[14]
Fei R, Wei QS, Xiang D. CD133: A cancer stem cells marker, is used in colorectal cancers[J]. World Journal of Gastroenterology, 2013, 19(17): 2603-2611.
[15]
Grosse-Gehling P, Fargeas CA, Dittfeld C, et al. CD133 as a biomarker for putative cancer stem cells in solid tumours: limitations, problems and challenges[J]. The Journal of Pathology, 2013, 229(3): 355-378.
[16]
Nguyen PH, Giraud J, Chambonnier L, et al. Characterization of biomarkers of tumorigenic and chemoresistant cancer stem cells in human gastric carcinomabiomarkers of tumorigenic and chemoresistant gastric CSCs[J]. Clinical Cancer Research, 2017, 23(6): 1586-1597.
[17]
Wang W, Wan P, Lai F, et al. Double-stranded RNA targeting calmodulin reveals a potential target for pest management of Nilaparvata lugens[J]. Pest management science, 2018, 74(7): 1711-1719.
[18]
Terraneo N, Jacob F, Peitzsch C, et al. L1 cell adhesion molecule confers radioresistance to ovarian cancer and defines a new cancer stem cell population[J]. Cancers, 2020, 12(1): 217.
[19]
Mansoori B, Mohammadi A, Naghizadeh S, et al. miR-330 suppresses EMT and induces apoptosis by downregulating HMGA2 in human colorectal cancer[J]. Journal of Cellular Physiology, 2020, 235(2): 920-931.
[20]
Zhang Y, Ma LN, Xie Y. MiRNA-802 inhibits the metastasis of colorectal cancer by targeting FOXE1[J]. European review for medical and pharmacological sciences, 2020, 24(4): 1778-1785.
[21]
陈贝贝, 吕慧芳, 别良玉, 等. MicroRNA-375表达对大肠癌细胞生物学特性的影响[J]. 现代肿瘤医学, 2017, 25(22): 3558-3563.
[22]
杨秀春, 王盼, 余涛, 等. miRNA-107在胃癌、结直肠癌及其癌前病变中的表达水平及临床意义[J]. 中国中西医结合消化杂志, 2020, 28(1): 52-57.
[23]
张学明, 裴永彬, 张峰, 等. 血浆微RNA-224在结直肠癌中的诊断价值[J]. 肿瘤, 2014, 34(7): 623-628.
[24]
Bhattacharya R, Ye XC, Wang R, et al. Intracrine VEGF signaling mediates the activity of prosurvival pathways in human colorectal cancer cells[J]. Cancer research, 2016, 76(10): 3014-3024.
[25]
Bhattacharya R, Fan F, Wang R, et al. Intracrine VEGF signalling mediates colorectal cancer cell migration and invasion[J]. British journal of cancer, 2017, 117(6): 848-855.
[1] 康夏, 田浩, 钱进, 高源, 缪洪明, 齐晓伟. 骨织素抑制破骨细胞分化改善肿瘤骨转移中骨溶解的机制研究[J]. 中华乳腺病杂志(电子版), 2023, 17(06): 329-339.
[2] 江艺, 张小进, 沈佳佳. 胆囊癌伴肝多发转移手术治疗(腹腔镜下胆囊癌切除+淋巴结清扫+肝Ⅴ、Ⅵ、Ⅶ段切除)[J]. 中华普通外科学文献(电子版), 2023, 17(06): 412-412.
[3] 代莉, 邓恢伟, 郭华静, 黄芙蓉. 术中持续输注艾司氯胺酮对腹腔镜结直肠癌手术患者术后睡眠质量的影响[J]. 中华普通外科学文献(电子版), 2023, 17(06): 408-412.
[4] 王得晨, 杨康, 杨自杰, 归明彬, 屈莲平, 张小凤, 高峰. 结直肠癌微卫星稳定状态和程序性死亡、吲哚胺2,3-双加氧酶关系的研究进展[J]. 中华普通外科学文献(电子版), 2023, 17(06): 462-465.
[5] 唐旭, 韩冰, 刘威, 陈茹星. 结直肠癌根治术后隐匿性肝转移危险因素分析及预测模型构建[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 16-20.
[6] 张生军, 赵阿静, 李守博, 郝祥宏, 刘敏丽. 高糖通过HGF/c-met通路促进结直肠癌侵袭和迁移的实验研究[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 21-24.
[7] 李婷, 张琳. 血清脂肪酸代谢物及维生素D水平与结直肠癌发生的关系研究[J]. 中华普外科手术学杂志(电子版), 2023, 17(06): 661-665.
[8] 常剑, 邱峰, 毛郁琪. 摄食抑制因子-1与腹腔镜结直肠癌根治术后肝转移的关系分析[J]. 中华普外科手术学杂志(电子版), 2023, 17(05): 502-505.
[9] 关旭, 王锡山. 基于外科与免疫视角思考结直肠癌区域淋巴结处理的功与过[J]. 中华结直肠疾病电子杂志, 2023, 12(06): 448-452.
[10] 顾睿祈, 方洪生, 蔡国响. 循环肿瘤DNA检测在结直肠癌诊治中的应用与进展[J]. 中华结直肠疾病电子杂志, 2023, 12(06): 453-459.
[11] 倪文凯, 齐翀, 许小丹, 周燮程, 殷庆章, 蔡元坤. 结直肠癌患者术后发生延迟性肠麻痹的影响因素分析[J]. 中华结直肠疾病电子杂志, 2023, 12(06): 484-489.
[12] 范小彧, 孙司正, 鄂一民, 喻春钊. 梗阻性左半结肠癌不同手术治疗方案的选择应用[J]. 中华结直肠疾病电子杂志, 2023, 12(06): 500-504.
[13] 孙昕, 程海波, 沈卫星. 基于全转录组学探讨仙连解毒方治疗Ⅲ期结直肠癌患者的疗效机制[J]. 中华消化病与影像杂志(电子版), 2023, 13(05): 277-283.
[14] 刘代江, 蒋俊艳, 万晓强, 马莎英. 结直肠癌肝转移患者生存状况及预后影响因素分析[J]. 中华消化病与影像杂志(电子版), 2023, 13(05): 284-288.
[15] 孔凡彪, 杨建荣. 肝脏基础疾病与结直肠癌肝转移之间关系的研究进展[J]. 中华临床医师杂志(电子版), 2023, 17(07): 818-822.
阅读次数
全文


摘要