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中华结直肠疾病电子杂志 ›› 2022, Vol. 11 ›› Issue (05) : 353 -360. doi: 10.3877/cma.j.issn.2095-3224.2022.05.001

所属专题: 指南共识

指南与共识

结直肠癌靶向治疗中国专家共识
中国医师协会结直肠肿瘤专业委员会, 中国抗癌协会大肠癌专业委员会, 国家癌症中心国家肿瘤质控中心结直肠癌质控专家委员会   
  • 收稿日期:2022-09-02 出版日期:2022-10-25

Chinese expert consensus on targeted therapy for colorectal cancer

Colorectal Cancer Committee of Chinese Medical Doctor Association, Colorectal Cancer Professional Committee of Chinese Anti-Cancer Association, Expert Committee on Quality Control of Colorectal Cancer of Center National Cancer/National Cancer Quality Control Center   

  • Received:2022-09-02 Published:2022-10-25
引用本文:

中国医师协会结直肠肿瘤专业委员会, 中国抗癌协会大肠癌专业委员会, 国家癌症中心国家肿瘤质控中心结直肠癌质控专家委员会. 结直肠癌靶向治疗中国专家共识[J]. 中华结直肠疾病电子杂志, 2022, 11(05): 353-360.

Colorectal Cancer Committee of Chinese Medical Doctor Association, Colorectal Cancer Professional Committee of Chinese Anti-Cancer Association, Expert Committee on Quality Control of Colorectal Cancer of Center National Cancer/National Cancer Quality Control Center. Chinese expert consensus on targeted therapy for colorectal cancer[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2022, 11(05): 353-360.

近年来,随着新型靶向药物的应用,靶向治疗已成为结直肠癌个体化治疗和综合治疗的一线方案,中国医师协会结直肠肿瘤专业委员会、中国抗癌协会大肠癌专业委员会以及国家癌症中心国家肿瘤质控中心结直肠癌质控专家委员会组织全国多位专家,讨论了结直肠肿瘤靶向药物的规范应用。

In recent years, with the application of new targeted drugs, it has become a first-line scheme for individualized and comprehensive treatment of colorectal cancer. Colorectal Cancer Committee of Chinese Medical Doctor Association, Colorectal Cancer Professional Committee of Chinese Anti-Cancer Association, Expert Committee on Quality Control of Colorectal Cancer of Center National Cancer/National Cancer Quality Control Center organized many experts nationwide to discuss the standardized application of colorectal cancer targeted drugs.

[1]
Zheng R, Zhang S, Zeng H, et al. Cancer incidence and mortality in China, 2016[J]. Journal of the National Cancer Center, 2022, 2(1): 1-9.
[2]
Ferlay J, Ervik M, Lam F, et al. Global cancer observatory: cancer today[DB/OL]. Lyon, France: International Agency for Research on Cancer. accessed[15032020].

URL    
[3]
Beppu T, Emi Y, Tokunaga S, et al. Liver resectability of advanced liver-limited colorectal liver metastases following mFOLFOX6 with bevacizumab (KSCC0802 Study)[J]. Anticancer Res, 2014, 34(11): 6655-6662.
[4]
Siegel R, Ma J, Zou Z, et al. Cancer statistics, 2014[J]. CA Cancer J Clin, 2014, 64(1): 9-29.
[5]
王延召, 雷福明. 结直肠癌靶向药物治疗[J]. 实用临床医学, 2016, 17(3): 101-103.
[6]
姜帅, 蔡晧东, 董梅. 应重视对新型抗肿瘤药物不良反应的监测[J]. 药物不良反应杂志, 2020, 22(4): 217-220.
[7]
Fuchs CS, Tomasek J, Yong CJ, et al. REGARD Trial Investigators. Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial[J]. Lancet, 2014, 383(9911): 31-39.
[8]
Wilke H, Muro K, Van Cutsem E, et al. Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial[J]. Lancet Oncol, 2014, 15(11): 1224-1235.
[9]
Strumberg D, Schultheis B. Regorafenib for cancer[J]. Expert Opin Investig Drugs, 2012, 21(6): 879-889.
[10]
Roper J, Sinnamon MJ, Coffee EM, et al. Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer[J]. Cancer Lett, 2014, 347:204-211.
[11]
Kim D, Xue JY, Lito P. Targeting KRAS(G12C): from inhibitory mechanism to modulation of antitumor effects in patients[J]. Cell, 2020, 183(4): 850-859.
[12]
Hong DS, Fakih MG, Strickler JH, et al. KRASG12C inhibition with sotorasib in advanced solid tumors[J]. N Engl J Med, 2020, 383(13): 1207-1217.
[13]
Jones JC, Renfro LA, Al-Shamsi HO, et al. Non-V600 BRAF mutations define a clinically distinct molecular subtype of metastatic colorectal cancer[J]. J Clin Oncol, 2017, 35(23): 2624-2630.
[14]
Ward RL, Hicks S, Hawkins NJ. Population-based molecular screening for Lynch syndrome: implications for personalized medicine[J]. J Clin Oncol, 2013, 31(20):2554-2562.
[15]
Jiang W, Cai MY, Li SY, et al. Universal screening for Lynch syndrome in a large consecutive cohort of Chinese colorectal cancer patients: High prevalence and unique molecular features[J]. Int J Cancer, 2019, 144(9): 2161-2168.
[16]
Yaeger R, Chatila WK, Lipsyc MD, et al. Clinical sequencing defines the genomic landscape of metastatic colorectal cancer[J]. Cancer Cell, 2018, 33(1): 125-136.e3.
[17]
Sartore-Bianchi A, Amatu A, Porcu L, et al. HER2 positivity predicts unresponsiveness to EGFR-targeted treatment in metastatic colorectal cancer[J]. Oncologist, 2019, 24(10): 1395-1402.
[18]
Sartore-Bianchi A, Trusolino L, Martino C, et al. Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): a proof-of-concept, multicentre, open-label, phase 2 trial[J]. Lancet Oncol, 2016, 17(6): 738-746.
[19]
Meric-Bernstam F, Hurwitz H, Raghav KPS, et al. Pertuzumab plus trastuzumab for HER2-amplified metastatic colorectal cancer (MyPathway): an updated report from a multicentre, open-label, phase 2a, multiple basket study[J]. Lancet Oncol, 2019, 20(4): 518-530.
[20]
Guo Y, Guo XL, Wang S, et al. Genomic alterations of NTRK, POLE, ERBB2, and microsatellite instability status in Chinese patients with colorectal cancer[J]. Oncologist, 2020, 5(11): e1671-e1680.
[21]
Wang H, Li ZW, Ou Q, et al. NTRK fusion positive colorectal cancer is a unique subset of CRC with high TMB and microsatellite instability[J]. Cancer Med, 2022, 11(13): 2541-2549.
[22]
Wollina U. Update of cetuximab for non-melanoma skin cancer[J]. Expert Opin Biol Ther, 2014, 14(2): 271-276.
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