切换至 "中华医学电子期刊资源库"

中华结直肠疾病电子杂志 ›› 2021, Vol. 10 ›› Issue (05) : 524 -527. doi: 10.3877/cma.j.issn.2095-3224.2021.05.013

综述

阴部神经调节在肛门直肠疾病的应用及研究进展
李怡廷1, 吴桑嗓1, 麻琦瑶1, 倪敏1,()   
  1. 1. 210001 南京中医药大学附属南京中医院肛肠科
  • 收稿日期:2021-04-27 出版日期:2021-10-25
  • 通信作者: 倪敏
  • 基金资助:
    江苏省重点研发计划(社会发展)项目(BE2018612)

Application and research progress on the pudendal nerve modulation in the analrectal disease

Yiting Li1, Sangsang Wu1, Qiyao Ma1, Min Ni1,()   

  1. 1. Department of Anorectal Surgery, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing 210001, China
  • Received:2021-04-27 Published:2021-10-25
  • Corresponding author: Min Ni
引用本文:

李怡廷, 吴桑嗓, 麻琦瑶, 倪敏. 阴部神经调节在肛门直肠疾病的应用及研究进展[J/OL]. 中华结直肠疾病电子杂志, 2021, 10(05): 524-527.

Yiting Li, Sangsang Wu, Qiyao Ma, Min Ni. Application and research progress on the pudendal nerve modulation in the analrectal disease[J/OL]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2021, 10(05): 524-527.

神经调控是指通过各种形式的刺激对神经元或神经信号转导发挥兴奋、抑制或调节作用,以强化神经连接、增强神经可塑性的治疗方法。神经调节在肛门直肠疾病中应用广泛,包括骶神经刺激、胫神经刺激、迷走神经刺激、阴部神经刺激等治疗方法。目前对阴部神经刺激的研究尚少,认识尚不清晰,故本文围绕阴部神经调节在肛门直肠疾病中的应用及研究现状进行综述。

Neuromodulation refers to the method that plays an exciting, inhibitory or regulatory role on neurons or nerve signal transduction through various forms of stimulation, so as to strengthen neural connections and enhance neuroplasticity. Neuromodulation is widely used in colorectal anal diseases, including sacral nerve stimulation, tibial nerve stimulation, vagus nerve stimulation, pudendal nerve stimulation and other treatments. There are few studies on the pudendal nerve stimulation, and the understanding is still unclear. Therefore, this paper reviews application and research progress of pudendal nerve modulation.

图1 阴部神经解剖图。1梨状肌;2阴部神经;3骶棘韧带;4直肠下神经;5会阴神经;6阴茎背神经。(图片作者:李怡廷)
[1]
James ND, McMahon SB, Field-Fote EC, et al. Neuromodulation in the restoration of function after spinal cord injury[J]. Lancet Neurol, 2018, 17(10): 905-917.
[2]
Chen JD, Yin J, Wei W. Electrical therapies for gastrointestinal motility disorders[J]. Expert Rev Gastroenterol Hepatol, 2017, 11(5): 407-418.
[3]
Sarveazad A, Babahajian A, Amini N, et al. Posterior tibial nerve stimulation in fecal incontinence: a systematic review and meta-analysis [J]. Basic Clin Neurosci, 2019, 10(5): 419-431.
[4]
Wang YB, de Lartigue G, Page AJ. Dissecting the role of subtypes of gastrointestinal vagal afferents [J]. Front Physiol, 2020,11: 643.
[5]
Robert R, Labat JJ, Riant T, et al. The pudendal nerve: clinical and therapeutic morphogenesis, anatomy, and physiopathology[J]. Neurochirurgie, 2009, 55(4-5): 463-469.
[6]
Uz A, Apan A, Erbil KM, et al. A new approach for pudendal nerve exposure and its clinical significance[J]. Anat Sci Int, 2005, 80(3): 163-166.
[7]
Van Koughnett JA, da Silva G. Anorectal physiology and testing[J]. Gastroenterol Clin North Am, 2013, 42(4): 713-728.
[8]
倪敏, 丁义江, 丁曙晴, 等. 功能性便秘患者经颅磁刺激运动诱发电位的研究[J]. 南京医科大学学报(自然科学版), 2011, 31(11): 1674-1678.
[9]
Rao SS, Coss-Adame E, Tantiphlachiva K, et al. Translumbar and transsacral magnetic neurostimulation for the assessment of neuropathy in fecal incontinence[J]. Dis Colon Rectum, 2014, 57(5): 645-652.
[10]
倪敏, 丁曙晴, 皇甫少华, 等. 功能性排便障碍患者经腰刺激运动诱发电位的研究[J]. 第三军医大学学报, 2013, 35(21): 2292-2294.
[11]
Reitz A, Gobeaux N, Mozer P, et al. Topographic anatomy of a new posterior approach to the pudendal nerve for stimulation[J]. Eur Urol, 2007, 51(5): 1350-1355.
[12]
Yoo PB, Klein SM, Grafstein NH, et al. Pudendal nerve stimulation evokes reflex bladder contractions in persons with chronic spinal cord injury[J]. Neurourol Urodyn, 2007, 26(7): 1020-1023.
[13]
George AT, Dudding TC, Gurmany S, et al. Pudendal nerve stimulation for bowel dysfunction in complete cauda equina syndrome[J]. Ann Surg, 2014, 259(3): 502-507.
[14]
Giani I, Novelli E, Martina S, et al. The effect of sacral nerve modulation on cerebral evoked potential latency in fecal incontinence and constipation[J]. Ann Surg, 2011, 254(1): 90-96.
[15]
蔡少康, 蔡毅, 李颖波, 等. 长时程骶神经电刺激治疗腰椎术后肛门直肠疼痛的临床疗效观察[J]. 局解手术学杂志, 2019, 28(1): 63-66.
[16]
Wang S, Lv J, Feng X, et al. Efficacy of electrical pudendal nerve stimulation versus transvaginal electrical stimulation in treating female idiopathic urgency urinary incontinence[J]. J Urol, 2017, 197(6): 1496-1501.
[17]
Liu Z, Liu Y, Xu H, et al. Effect of electroacupuncture on urinary leakage among women with stress urinary incontinence: a randomized clinical trial[J]. JAMA, 2017, 317(24): 2493-2501.
[18]
王文志, 姚勇, 项小天, 等. 经皮穿刺阴部神经电刺激治疗女性膀胱过度活动症的疗效观察[J]. 中华全科医学, 2018, 16(9): 1487-1489.
[19]
Bock S, Folie P, Wolff K, et al. First experiences with pudendal nerve stimulation in fecal incontinence: a technical report[J]. Tech Coloproctol, 2010, 14(1): 41-44.
[20]
Possover M. A new technique of laparoscopic implantation of stimulation electrode to the pudendal nerve for treatment of refractory fecal incontinence and/or overactive bladder with urinary incontinence[J]. J Minim Invasive Gynecol, 2014, 21(5): 729.
[21]
胡永生. 中枢性疼痛与神经外科止痛手术[J]. 中国微侵袭神经外科杂志, 2013, 18(2): 49-52.
[22]
Ness TJ, DeWitte C, McNaught J, et al. Spinal mechanisms of pudendal nerve stimulation-induced inhibition of bladder hypersensitivity in rats[J]. Neurosci Lett, 2018, 686: 181-185.
[23]
Li ALK, Marques R, Oliveira A, et al. Laparoscopic implantation of electrodes for bilateral neuromodulation of the pudendal nerves and S3 nerve roots for treating pelvic pain and voiding dysfunction[J]. Int Urogynecol J, 2018, 29(7): 1061-1064.
[24]
Gregory NS, Terkawi AS, Prabhakar NK, et al. Peripheral nerve stimulation for pudendal neuralgia: a technical note[J]. Pain Med, 2020, 21(Suppl 1): S51-S55.
[25]
Schmidt RA. Technique of pudendal nerve localization for block or stimulation[J]. J Urol, 1989, 142(6): 1528-1531.
[26]
Peters KM, Feber KM, Bennett RC. Sacral versus pudendal nerve stimulation for voiding dysfunction: a prospective, single-blinded, randomized, crossover trial[J]. Neurourol Urodyn, 2005, 24(7): 643-647.
[27]
Spinelli M, Malaguti S, Giardiello G, et al. A new minimally invasive procedure for pudendal nerve stimulation to treat neurogenic bladder: description of the method and preliminary data[J]. Neurourol Urodyn, 2005, 24(4): 305-309.
[28]
Heinze K, Hoermann R, Fritsch H, et al. Comparative pilot study of implantation techniques for pudendal neuromodulation: technical and clinical outcome in first 20 patients with chronic pelvic pain[J]. World J Urol, 2015, 33(2): 289-294.
[29]
Jarrett ME, Mowatt G, Glazener CM, et al. Systematic review of sacral nerve stimulation for faecal incontinence and constipation[J]. Br J Surg, 2004, 91(12): 1559-1569.
[30]
Spinelli M, Sievert KD. Latest technologic and surgical developments in using interstim therapy for sacral neuromodulation: impact on treatment success and safety[J]. Eur Urol, 2008, 54(6): 1287-1296.
[31]
Khan U, Mason JM, Mecci M, et al. A prospective trial of temporary sacral nerve stimulation for constipation associated with neurological disease[J]. Colorectal Dis, 2014, 16(12): 1001-1009.
[32]
Peters KM, Feber KM, Bennett RC. A prospective, single-blind, randomized crossover trial of sacral vs pudendal nerve stimulation for interstitial cystitis[J]. BJU international, 2007, 100(4): 835-839.
[33]
Calabrò RS, Leo A, Bramanti P. Pudendal nerve stimulation: a potential tool for neurogenic bowel dysfunction![J]. Neurourol Urodyn, 2014, 33(3): 358-359.
[1] 赵丽霞, 王春霞, 陈一锋, 胡东平, 张维胜, 王涛, 张洪来. 内脏型肥胖对腹腔镜直肠癌根治术后早期并发症的影响[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 35-39.
[2] 吴晖, 佴永军, 施雪松, 魏晓为. 两种解剖入路下行直肠癌侧方淋巴结清扫的效果比较[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 40-43.
[3] 周世振, 朱兴亚, 袁庆港, 刘理想, 王凯, 缪骥, 丁超, 汪灏, 管文贤. 吲哚菁绿荧光成像技术在腹腔镜直肠癌侧方淋巴结清扫中的应用效果分析[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 44-47.
[4] 徐逸男. 不同术式治疗梗阻性左半结直肠癌的疗效观察[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 72-75.
[5] 杨建波, 马欢, 黄小梅, 刘华柱. 结肠镜辅助下EMR、CSP和RFA术治疗直径<1cm结直肠息肉的疗效和安全性比较[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 76-79.
[6] 李代勤, 刘佩杰. 动态增强磁共振评估中晚期低位直肠癌同步放化疗后疗效及预后的价值[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 100-103.
[7] 郑民华, 蒋天宇, 赵轩, 马君俊. 中国腹腔镜直肠癌根治术30年发展历程与未来[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 591-595.
[8] 池畔, 黄胜辉. 中国腹腔镜直肠癌根治术30年来的巨大进步[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 596-600.
[9] 李明, 屠松, 闫鹏, 钱军, 高鹏程, 许文山, 杨发英, 胡振涛, 单永玮. 应用前列腺电切镜引导置管治疗直肠低位吻合口漏研究[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 603-606.
[10] 李玲, 刘亚, 李培玲, 张秀敏, 李萍. 直肠癌患者术后肠道菌群的变化与抑郁症相关性研究[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 607-610.
[11] 赵梓竣, 兰运升. 改良一针法末端回肠造口术对低位直肠癌保肛术后应激反应及安全性的影响[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 611-614.
[12] 吴胜伟, 王志伟, 陈贵进, 刘序, 吴晓翔. 系膜肥厚低位直肠癌患者改良NOSES Ⅰ式手术的临床效果评价[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 615-618.
[13] 严虹霞, 王晓娟, 张毅勋. 2 型糖尿病对结直肠癌患者肿瘤标记物、临床病理及预后的影响[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(06): 483-487.
[14] 王湛, 李文坤, 杨奕, 徐芳, 周敏思, 苏珈仪, 王亚丹, 吴静. 炎症指标在早发性结直肠肿瘤中的应用[J/OL]. 中华临床医师杂志(电子版), 2024, 18(09): 802-810.
[15] 刘福成, 赵欣, 乔海朋, 刘晓峰, 张翀, 张宗明. 保留左结肠动脉的肠系膜下动脉根部淋巴结清扫对腹腔镜直肠癌根治术的疗效影响[J/OL]. 中华临床医师杂志(电子版), 2024, 18(07): 647-653.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?