切换至 "中华医学电子期刊资源库"

中华结直肠疾病电子杂志 ›› 2021, Vol. 10 ›› Issue (02) : 117 -121. doi: 10.3877/cma.j.issn.2095-3224.2021.02.002

所属专题: 文献

专家论坛

结直肠癌脑转移的临床进展
翟志超1, 王延召1, 雷福明1,()   
  1. 1. 100144 北京大学首钢医院胃肠外科
  • 收稿日期:2020-05-20 出版日期:2021-04-25
  • 通信作者: 雷福明

Clinical progress of brain metastasis in colorectal cancer

Zhichao Zhai1, Yanzhao Wang1, Fuming Lei1,()   

  1. 1. Department of Gastrointestinal Surgery, Peking University Shougang Hospital, Beijing 100144, China
  • Received:2020-05-20 Published:2021-04-25
  • Corresponding author: Fuming Lei
引用本文:

翟志超, 王延召, 雷福明. 结直肠癌脑转移的临床进展[J]. 中华结直肠疾病电子杂志, 2021, 10(02): 117-121.

Zhichao Zhai, Yanzhao Wang, Fuming Lei. Clinical progress of brain metastasis in colorectal cancer[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2021, 10(02): 117-121.

结直肠癌是全球常见的恶性肿瘤之一,肿瘤转移是导致治疗失败和癌症相关死亡的主要原因。结直肠癌脑转移虽然并不常见,可一旦发生,患者预后极差。目前,结直肠癌脑转移的发病机制仍有待探索,影响预后的因素也多种多样,针对脑转移的治疗也以综合治疗为主,患者发生脑转移后的生存时间也不尽相同,目前仍需要针对患者个体情况进行个体化治疗。

One of the most common malignancies cancer in the world is colorectal cancer, and of which metastasis was a leading cause of treatment failure and cancer-related death. Colorectal cancer brain metastases was rare, while the prognosis is really very poor. The pathogenesis of colorectal cancer brain metastasis is still without consensus up-to-date, because of various factors may affect the outcome. Treatment strategies for brain metastases were mainly based on comprehensive algorithm, and the overall survival was significant different from each other. So individual strategies for these cases might be explored in the future.

1
Jung M, Ahn JB, Chang JH, et al. Brain metastases from colorectal carcinoma: prognostic factors and outcome [J]. J Neurooncol, 2011, 101(1): 49-55.
2
Akil H, Perraud A, Jauberteau MO, et al. Tropomyosin-related kinase B/brain derived-neurotrophic factor signaling pathway as a potential therapeutic target for colorectal cancer [J]. World J Gastroenterol, 2016, 22(2): 490-500.
3
Lu X, Cai Y, Xia L, et al. Treatment modalities and relative survival in patients with brain metastasis from colorectal cancer [J]. Biosci Trends, 2019, 13(2): 182-188.
4
Luo D, Liu Q, Yu W, et al. Prognostic value of distant metastasis sites and surgery in stage IV colorectal cancer: a population-based study [J]. Int J Colorectal Dis, 2018, 33(9): 1241-1249.
5
Tapia Rico G, Price TJ, Karapetis C, et al. Brain metastasis in advanced colorectal cancer: results from the South Australian metastatic colorectal cancer (SAmCRC) registry [J]. Cancer Biol Med, 2017, 14(4): 371-376.
6
Shibahara I, Kanamori M, Watanabe T, et al. Clinical features of precocious, synchronous, and metachronous brain metastases and the role of tumor resection[J]. World Neurosurg, 2018, 113: e1-e9.
7
Quan JC, Guan X, Ma CX, et al. Prognostic scoring system for synchronous brain metastasis at diagnosis of colorectal cancer: A population-based study[J]. World J Gastrointest Oncol, 2020, 12(2): 195-204.
8
Chyun Y, Hayward E, Lokich J. Metastasis to the central nervous system from colorectal cancer[J]. Medical and Pediatric Oncology, 1980, 8(3): 305-308.
9
Hassan SM, Mubarik A, Muddassir S, et al. Brain metastasis in colorectal cancer presenting as refractory hypertension [J]. J Community Hosp Intern Med Perspect, 2018, 8(4): 215-219.
10
Mongan JP, Fadul CE, Cole BF, et al. Brain metastases from colorectal cancer: risk factors, incidence, and the possible role of chemokines[J]. Clin Colorectal Cancer, 2009, 8(2): 100-105.
11
Lee WLA, Michael-Titus AT, Shah DK. Hypoxic-ischaemic encephalopathy and the blood-brain barrier in neonates [J]. Developmental Neuroscience, 2017, 39(1-4): 49-58.
12
Abbott NJ. Blood-brain barrier structure and function and the challenges for CNS drug delivery [J]. Journal of Inherited Metabolic Disease, 2013, 36(3): 437-449.
13
Engelhardt B, Liebner S. Novel insights into the development and maintenance of the blood-brain barrier [J]. Cell and Tissue Research, 2014, 355(3): 687-699.

URL    
14
Adkins CE, Mohammad AS, Terrell-Hall TB, et al. Characterization of passive permeability at the blood-tumor barrier in five preclinical models of brain metastases of breast cancer [J]. Clinical & Experimental Metastasis, 2016, 33(4): 373-383.
15
Percy DB, Ribot EJ, Chen Y, et al. In vivo characterization of changing blood-tumor barrier permeability in a mouse model of breast cancer metastasis: a complementary magnetic resonance imaging approach[J]. Investigative Radiology, 2011, 46(11): 718-725.

URL    
16
Tie J, Lipton L, Desai J, et al. KRAS mutation is associated with lung metastasis in patients with curatively resected colorectal cancer [J]. Clinical Cancer Research: an Official Journal of the American Association for Cancer Research, 2011, 17(5): 1122-1130.

URL    
17
Aprile G, Casagrande M, De Maglio G, et al. Comparison of the molecular profile of brain metastases from colorectal cancer and corresponding primary tumors [J]. Future Oncol, 2017, 13(2): 135-144.
18
Kim J, Takeuchi H, Lam ST, et al. Chemokine receptor CXCR4 expression in colorectal cancer patients increases the risk for recurrence and for poor survival [J]. J Clin Oncol, 2005, 23(12): 2744-2753.
19
Zang YW, Gu XD, Xiang JB, et al. Brain metastases from colorectal cancer: microenvironment and molecular mechanisms[J]. Int J Mol Sci, 2012, 13(12): 15784-15800.
20
Zaytseva YY, Rychahou PG, Gulhati P, et al. Inhibition of fatty acid synthase attenuates CD44-associated signaling and reduces metastasis in colorectal cancer [J]. Cancer research, 2012, 72(6): 1504-1517.

URL    
21
Hotary K, Li XY, Allen E, et al. A cancer cell metalloprotease triad regulates the basement membrane transmigration program [J]. Genes & Development, 2006, 20(19): 2673-2686.
22
Kim DY, Ryu CG, Jung EJ, et al. Brain metastasis from colorectal cancer: a single center experience [J]. Ann Surg Treat Res, 2018, 94(1): 13-18.
23
Chu C, Navalkissoor S, Gillmore R. Neurological symptoms from a brain metastasis as the first presentation of colorectal cancer[J]. BMJ Case Rep, 2015, 2015: bcr2015210422.
24
Lei S, Ge Y, Tian S, et al. Colorectal cancer metastases to brain or bone and the relationship to primary tumor location: a population-based study [J]. J Gastrointest Surg, 2019, 24: 1833-1842.
25
Suzuki Y, Yamaguchi T, Matsumoto H, et al. Prognostic factors and treatment effects in patients with curatively resected brain metastasis from colorectal cancer [J]. Diseases of the Colon and Rectum, 2014, 57(1): 56-63.

URL    
26
Imaizumi J, Shida D, Narita Y, et al. Prognostic factors of brain metastases from colorectal cancer [J]. BMC Cancer, 2019, 19(1): 755.
27
Prabhu RS, Press RH, Patel KR, et al. Single-fraction stereotactic radiosurgery (SRS) alone versus surgical resection and SRS for large brain metastases: a multi-institutional analysis[J]. International Journal of Radiation Oncology, Biology, Physics, 2017, 99(2): 459-467.
28
Esmaeilzadeh M, Majlesara A, Faridar A, et al. Brain metastasis from gastrointestinal cancers: a systematic review [J]. Int J Clin Pract, 2014, 68(7): 890-899.
29
Paix A, Antoni D, Adeduntan R, et al. Stereotactic radiation therapy of brain metastases from colorectal cancer: A single institution cohort [J]. Cancer Radiother, 2017, 21(3): 199-204.
30
Mahajan A, Ahmed S, Mcaleer MF, et al. Post-operative stereotactic radiosurgery versus observation for completely resected brain metastases: a single-centre, randomised, controlled, phase 3 trial [J]. Lancet Oncol, 2017, 18(8): 1040-1048.
31
Brown PD, Ballman KV, Cerhan JH, et al. Postoperative stereotactic radiosurgery compared with whole brain radiotherapy for resected metastatic brain disease (NCCTG N107C/CEC•3): a multicentre, randomised, controlled, phase 3 trial [J]. Lancet Oncol, 2017, 18(8): 1049-1060.
32
Shi S, Sandhu N, Jin MC, et al. Stereotactic radiosurgery for resected brain metastases: single-institutional experience of over 500 cavities [J]. International Journal of Radiation Oncology, Biology, Physics, 2020, 106(4): 764-771.
33
Finkelmeier F, You SJ, Waidmann O, et al. Bevacizumab in combination with chemotherapy for colorectal brain metastasis[J]. J Gastrointest Cancer, 2016, 47(1): 82-88.
34
中国医师协会结直肠肿瘤专业委员会. 中国结直肠癌脑转移多学科综合治疗专家共识(2020版) [J/CD]. 中华结直肠疾病电子杂志, 2020, 9(2): 109-114.
35
Colorectal Cancer Committee of Chinese Medical Doctor Association.Guideline and Consensus Chinese experts consensus on multidisciplinary treatment of brain metastases from colorectal cancer (2020 version) [J/CD]. Chin J Colorec Dis (Electronic Edition), 2020, 9(2): 109-114.
36
中国医师协会结直肠肿瘤专业委员会. 中国结直肠癌脑转移多学科综合治疗专家共识(2020版) [J/CD]. 中华结直肠疾病电子杂志, 2020, 9(2): 109-114.
37
Arneson K, Mondschein J, Stavas M, et al. A phase I trial of concurrent sorafenib and stereotactic radiosurgery for patients with brain metastases [J]. J Neurooncol, 2017, 133(2): 435-442.
38
Noura S, Ohue M, Shingai T, et al. Brain metastasis from colorectal cancer: prognostic factors and survival [J]. J Surg Oncol, 2012, 106(2): 144-148.

URL    
39
Kye BH, Kim HJ, Kang WK, et al. Brain metastases from colorectal cancer: the role of surgical resection in selected patients [J]. Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland, 2012, 14(7): e378-e85.
40
Patel AR, Nedzi L, Lau S, et al. Neoadjuvant stereotactic radiosurgery before surgical resection of cerebral metastases [J]. World Neurosurg, 2018, 120: e480-e487.
41
Tokoro T, Okuno K, Hida J C, et al. Prognostic factors for patients with advanced colorectal cancer and symptomatic brain metastases [J]. Clin Colorectal Cancer, 2014, 13(4): 226-231.
42
Quan J, Ma C, Sun P, et al. Brain metastasis from colorectal cancer: clinical characteristics, timing, survival and prognostic factors [J]. Scand J Gastroenterol, 2019, 54(11): 1370-1375.
43
Christensen TD, Palshof JA, Larsen FO, et al. Risk factors for brain metastases in patients with metastatic colorectal cancer [J]. Acta Oncologica (Stockholm, Sweden), 2017, 56(5): 639-645.
44
Gu XD, Cai YT, Zhou YM, et al. Prognostic factors and multidisciplinary treatment modalities for brain metastases from colorectal cancer: analysis of 93 patients [J]. BMC Cancer, 2015, 15: 902.
[1] 江泽莹, 王安婷, 王姣丽, 陈慈, 周秋玲, 黄燕娟, 周芳, 薛琰, 周剑烽, 谭文勇, 杜美芳. 多种植物油组分预防肿瘤放化疗相关毒性反应的效果分析[J]. 中华损伤与修复杂志(电子版), 2023, 18(06): 523-527.
[2] 朴广昊, 李屹洲, 刘瑞, 赵建民, 王凌峰. 皮肤撕脱伤撕脱皮瓣活力早期评估与修复的研究进展[J]. 中华损伤与修复杂志(电子版), 2023, 18(06): 528-532.
[3] 唐旭, 韩冰, 刘威, 陈茹星. 结直肠癌根治术后隐匿性肝转移危险因素分析及预测模型构建[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 16-20.
[4] 张生军, 赵阿静, 李守博, 郝祥宏, 刘敏丽. 高糖通过HGF/c-met通路促进结直肠癌侵袭和迁移的实验研究[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 21-24.
[5] 彭旭, 邵永孚, 李铎, 邹瑞, 邢贞明. 结肠肝曲癌的诊断和外科治疗[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 108-110.
[6] 马伟强, 马斌林, 吴中语, 张莹. microRNA在三阴性乳腺癌进展中发挥的作用[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 111-114.
[7] 孔博, 张璟, 吕珂. 超声技术在复杂腹壁疝诊治中的作用[J]. 中华疝和腹壁外科杂志(电子版), 2023, 17(06): 670-673.
[8] 倪文凯, 齐翀, 许小丹, 周燮程, 殷庆章, 蔡元坤. 结直肠癌患者术后发生延迟性肠麻痹的影响因素分析[J]. 中华结直肠疾病电子杂志, 2023, 12(06): 484-489.
[9] 范小彧, 孙司正, 鄂一民, 喻春钊. 梗阻性左半结肠癌不同手术治疗方案的选择应用[J]. 中华结直肠疾病电子杂志, 2023, 12(06): 500-504.
[10] 蓝冰, 王怀明, 王辉, 马波. 局部晚期结肠癌膀胱浸润的研究进展[J]. 中华结直肠疾病电子杂志, 2023, 12(06): 505-511.
[11] 陆志峰, 周佳佳, 梁舒. 虚拟现实技术在治疗弱视中的临床应用研究进展[J]. 中华临床医师杂志(电子版), 2023, 17(08): 891-895.
[12] 李田, 徐洪, 刘和亮. 尘肺病的相关研究进展[J]. 中华临床医师杂志(电子版), 2023, 17(08): 900-905.
[13] 岳瑞雪, 孔令欣, 郝鑫, 杨进强, 韩猛, 崔国忠, 王建军, 张志生, 孔凡庭, 张维, 何文博, 李现桥, 周新平, 徐东宏, 胡崇珠. 乳腺癌HER2蛋白表达水平预测新辅助治疗疗效的真实世界研究[J]. 中华临床医师杂志(电子版), 2023, 17(07): 765-770.
[14] 李变, 王莉娜, 桑田, 李珊, 杜雪燕, 李春华, 张兴云, 管巧, 王颖, 冯琪, 蒙景雯. 亚低温技术治疗缺氧缺血性脑病新生儿的临床分析[J]. 中华临床医师杂志(电子版), 2023, 17(06): 639-643.
[15] 戴俊, 李硕, 曹影, 汪守峰, 宋红毛, 蔡菁菁, 邵敏, 陈莉, 程雷, 怀德. 鼻内镜下改良高选择性翼管神经低温等离子消融术对中重度变应性鼻炎的效果研究[J]. 中华临床医师杂志(电子版), 2023, 17(06): 689-693.
阅读次数
全文


摘要