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中华结直肠疾病电子杂志 ›› 2019, Vol. 08 ›› Issue (05) : 447 -453. doi: 10.3877/cma.j.issn.2095-3224.2019.05.003

所属专题: 文献

青年专家论坛

结肠癌围手术期治疗进展
邱萌1,(), 陈烨1   
  1. 1. 610041 成都,四川大学华西医院肿瘤中心腹部肿瘤科
  • 收稿日期:2019-09-12 出版日期:2019-10-25
  • 通信作者: 邱萌
  • 基金资助:
    国家重点研发项目精准专项精准医疗集成应用示范体系建设项目(No.2017YFC0910004)

Recent advances in neoadjuvant and adjuvant treatment of colon cancer

Meng Qiu1,(), Ye Chen1   

  1. 1. Department of Abdominal Oncology, Cancer Center, the State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
  • Received:2019-09-12 Published:2019-10-25
  • Corresponding author: Meng Qiu
  • About author:
    Corresponding author: Qiu Meng, Email:
引用本文:

邱萌, 陈烨. 结肠癌围手术期治疗进展[J]. 中华结直肠疾病电子杂志, 2019, 08(05): 447-453.

Meng Qiu, Ye Chen. Recent advances in neoadjuvant and adjuvant treatment of colon cancer[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2019, 08(05): 447-453.

结肠癌术后辅助化疗特别是氟尿嘧啶类联合奥沙利铂化疗已明显降低结肠癌术后的复发转移,成为Ⅱ和Ⅲ期患者的标准治疗方法。随着外科技术和理念的更新以及对肿瘤生物学特别是分子标记物认识的深入,辅助化疗的个体化和分层治疗策略成为了研究热点,同时新辅助治疗模式在直肠癌中的成功也使结肠癌新辅助化疗日渐受到关注。本文将梳理最新结肠癌复发、治疗风险评估和围手术期治疗进展,以协助临床医生更好地理解结肠癌的个体化治疗并运用于临床工作中。

Adjuvant chemotherapy especially fluoropyrimidines combinations with oxaliplatin has reduced the risk of tumor recurrence and improved survival for patients with resected colon cancer and becomes the standard care for stage Ⅱ/Ⅲ colon cancer. Recent advances in surgical conception and in understanding the biologic characteristics especially prognostic and predict biomarkers of colon cancer are expected to translate into individualized therapeutic strategies tailored to select patients. And with the success of perioperative treatment in rectal cancer, increasing concern is raised in the neoadjuvant chemotherapy of local advanced colon cancer. This article focuses on the advances in neoadjuvant and adjuvant therapy of colon cancer and we hope to assist the clinician to define the optimal perioperativet treatments for patients in routine clinical practice.

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