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中华结直肠疾病电子杂志 ›› 2017, Vol. 06 ›› Issue (04) : 316 -319. doi: 10.3877/cma.j.issn.2095-3224.2017.04.010

所属专题: 文献

综述

卵巢切除术在结直肠癌综合治疗中的研究进展
李群1, 黄镜1,()   
  1. 1. 100021 北京,国家癌症中心/中国医学科学院北京协和医学院肿瘤医院肿瘤内科
  • 收稿日期:2017-03-16 出版日期:2017-08-25
  • 通信作者: 黄镜

Research progress of oophorectomy in the combined modality therapy of colorectal cancer

Qun Li1, Jing Huang1,()   

  1. 1. Department of Medical Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
  • Received:2017-03-16 Published:2017-08-25
  • Corresponding author: Jing Huang
  • About author:
    Corresponding author: Huang Jing, Email:
引用本文:

李群, 黄镜. 卵巢切除术在结直肠癌综合治疗中的研究进展[J]. 中华结直肠疾病电子杂志, 2017, 06(04): 316-319.

Qun Li, Jing Huang. Research progress of oophorectomy in the combined modality therapy of colorectal cancer[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2017, 06(04): 316-319.

卵巢转移是结直肠癌转移的少见形式,预后差。卵巢转移灶相对于其他转移部位对化疗的敏感性更差,因此,卵巢切除术在结直肠癌综合治疗中的价值值得进一步探索,本文通过文献复习从手术切除卵巢转移灶和预防性卵巢切除2方面对其进行总结。一些回顾性研究结果显示对卵巢转移灶行积极的手术切除治疗可能对晚期结直肠癌患者的生存有益,仍迫切需要大样本前瞻性随机对照研究为手术治疗结直肠癌卵巢转移提供循证依据。考虑到结直肠癌患者卵巢转移的发生率非常低,有研究者并不支持积极地预防性切除卵巢,但对于更易存在卵巢微转移的部分筛选人群,行预防性卵巢切除则可能带来生存获益,值得进一步探索。

Ovarian metastases are uncommon in women with colorectal cancer (CRC) and harbor poor prognosis. Due to less sensitivity to systemic chemotherapy of ovarian metastases compared to extraovarian metastases, oophorectomy in the comprehensive treatment of CRC deserves further study. This study reviewed researches on oophorectomy in the comprehensive treatment of CRC and summarized form two aspects including ovarian metastatectomy and prophylactic oophorectomy. Retrospective researches had shown potential survival benefits from optimal ovarian metastatectomy in CRC patients with ovarian metastasis, but randomized prospective trials are urgently warranted. Because of the low incidence of ovarian metastases from CRC, prophylactic oophorectomy in colorectal cancer surgery was not recommended by some researchers. However, strictly selected patients with clinical findings suggestive of ovarian micrometastasis might obtain survival benefits by prophylactic oophorectomy, which deserves further study.

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