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中华结直肠疾病电子杂志 ›› 2016, Vol. 05 ›› Issue (05) : 380 -385. doi: 10.3877/cma.j.issn.2095-3224.2016.05.003

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左、右半结肠癌"两种疾病论"的研究进展
胡俊杰1, 熊治国1,()   
  1. 1. 430071 武汉,湖北省肿瘤医院胃肠外科;湖北省结直肠癌临床医学研究中心
  • 收稿日期:2016-05-29 出版日期:2016-10-25
  • 通信作者: 熊治国

The research advances of a new theory: right-and left-sided colon cancer may be two different kinds of clinical disease

Junjie Hu1, Zhiguo Xiong1,()   

  1. 1. Department of Gastrointestinal Surgery, Hubei Colorectal Cancer Clinical Research Center, Hubei Cancer Hospital, Wuhan 430071, China
  • Received:2016-05-29 Published:2016-10-25
  • Corresponding author: Zhiguo Xiong
  • About author:
    Corresponding author: Xiong Zhiguo, Email:
引用本文:

胡俊杰, 熊治国. 左、右半结肠癌"两种疾病论"的研究进展[J/OL]. 中华结直肠疾病电子杂志, 2016, 05(05): 380-385.

Junjie Hu, Zhiguo Xiong. The research advances of a new theory: right-and left-sided colon cancer may be two different kinds of clinical disease[J/OL]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2016, 05(05): 380-385.

左、右半结肠胚胎起源不同,肿瘤发生的分子生物学机制不同。统计数据显示右半结肠癌中女性患者及高龄患者比例高;组织学常表现为分化较差的腺癌;MSI(+)、CIMP(+)及BRAF基因突变型更多见。左、右半结肠癌的预后差异与期别相关,Ⅰ期预后相似,Ⅱ期右半结肠癌预后较好,Ⅲ/Ⅳ期右半结肠癌预后较差。结直肠癌不同部位肿瘤分子生物学行为不同,临床治疗上不应被笼统地视为一种疾病,在当前个体化、精准化治疗时代,区分结直肠癌肿瘤部位对评价患者预后及药物疗效尤为重要。

Recently, researchers gradually discovered that the right and left colon cancer has significant difference in molecular mechanism of carcinogenesis, it was possibly due to intestinal epithelium derives from different embryologic origin. Patients with right-sided colon cancer were more likely to be elder, women and poorly differentiated. Frequencies of CIMP+ , MSI+ , BRAF+ were higher in right-sided colon cancer. The prognostic differences between right-and left-colon cancer were associated with tumor stage. For stageⅠthe survival was similar. Right-sided cancer had better survival for stage Ⅱ, but worse survival for stage Ⅲ/Ⅳ. Colorectal cancer origined from different location had different biological behavior, and it should not be regarded as a single entity. In the current era of personalized and precision medicine, tumor locations was quite important in the evaluation of prognosis and drug efficacy.

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