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中华结直肠疾病电子杂志 ›› 2016, Vol. 05 ›› Issue (04) : 315 -318. doi: 10.3877/cma.j.issn.2095-3224.2016.04.007

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论著

节律基因hBmal1在人结肠癌中的表达及临床意义
鲁力1, 熊治国1, 谢敏1, 熊莉娜2,()   
  1. 1. 430000 武汉,湖北省肿瘤医院胃肠外科
    2. 华中科技大学同济医学院附属梨园医院消化内科
  • 收稿日期:2016-05-21 出版日期:2016-08-25
  • 通信作者: 熊莉娜
  • 基金资助:
    湖北省自然科学基金资助项目(No.2013CFB117); 华中科技大学青年教师基金资助项目(No.2013QN128)

Significance and expression of hBmal1 in human colon carcinoma

Li Lu1, Zhiguo Xiong1, Min Xie1, Lina Xiong2,()   

  1. 1. Department of Gastrointestinal Surgery, Cancer Hospital of Hubei Province, Wuhan 430000, China
    2. Department of Digestive Disease, Liyuan Hospital, Huazhong University of Science & Technology, Wuhan 430077, China
  • Received:2016-05-21 Published:2016-08-25
  • Corresponding author: Lina Xiong
  • About author:
    Corresponding author: Xiong Lina, Email:
引用本文:

鲁力, 熊治国, 谢敏, 熊莉娜. 节律基因hBmal1在人结肠癌中的表达及临床意义[J/OL]. 中华结直肠疾病电子杂志, 2016, 05(04): 315-318.

Li Lu, Zhiguo Xiong, Min Xie, Lina Xiong. Significance and expression of hBmal1 in human colon carcinoma[J/OL]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2016, 05(04): 315-318.

目的

检测hBmal1在人结肠癌中的表达,探讨其临床意义。

方法

应用免疫组织化学方法检测湖北省肿瘤医院30例人结肠癌患者中hBmal1的表达,以图像分析软件进行相关测定,并分析其表达与临床及病理常用指标的关系。

结果

人结肠癌组织和癌旁正常对照组织中hBmal1表达阳性率为76.67%(23/30) vs 26.67%(8/30)(χ2=15.016,P<0.01);hBmal1在人结肠癌Dukes分期B、C期中强阳性表达率为46.15%(6/13) vs 88.24%(15/17)(χ2=6.212,P=0.013)。

结论

hBmal1在人结肠癌组织中有高表达,可能与癌症的发生发展侵袭转移有关。

Objective

The aim of study is to investigate the expression of hBmal1 gene in human colon carcinoma tissue and their relation to invasion and metabasis of colon carcinoma.

Methods

Immunochemical staining was performed to detect the expression of hBmal1 protein in 30 cases of colon carcinoma tissues and 30 cases of normal tissues from Cancer Hospital of Hubei Province.

Results

The positive expression rate of hBmal1 in colon carcinoma tissues and in adjacent noncancerous tissues were 76.67% (23/30) vs 26.67% (8/30) (χ2=15.016, P<0.01). The strong positive expression rate of hBmal1 in B and C Dukes stage of were 46.15% (6/13) vs 88.24% (15/17) (χ2=6.212, P=0.013).

Conclusions

Increased expression of hBmal1 gene contributes to occurrence and development of colon carcinoma.

表1 hBmal1在结肠癌组织、癌旁正常组织中的表达[例(%)]
图1 hBmal1的表达(×200)
表2 hBmal1在结肠癌组织中的表达和分化程度的关系[例(%)]
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