观察骶神经调节术(Sacral Neuromodulation，SNM)治疗顽固性便秘的临床效果。

采用骶神经调节测试系统，经皮穿刺刺激调节骶神经根治疗12例顽固性便秘患者，通过排便日记、Cleveland便秘评分及患者症状评分评价疗效。

在测试治疗阶段11例患者便秘症状明显改善，每周排便次数、排便量明显增加。其中10例接受永久性骶神经调节器植入术，永久性植入术后平均随访7.8个月(1～20个月)，每周排便次数从(0.80±0.42)次增加到(8.10±2.47)次(P<0.01)；每次排便时间从(21.10±10.06)分钟减少到(3.70±0.67)分钟(P<0.01)；Cleveland便秘评分从(21.10±4.99)分下降到(8.90±0.88)分(P<0.01)；VAS评分从(9.90±3.28)分增加到(84.10±4.63)分(P<0.01)。

SNM是一种安全、可逆、有效、微创的治疗顽固性便秘的新方法，适于对传统治疗无效的顽固性便秘患者。

To assess the clinical efficacy of sacral neuromodulation(SNM)in patients with intractable constipation.

A total of 12 patients with intractable constipation were treated with pereutaneous test stimulation of the sacral nerve root and were assessed by sacral nerve stimulation system, Then the clinical efficacy was assessed by the bowel habit diary, the clinic constipation scores, subjective questionnaire and clinical signs.

The symptoms of constipation were improved significantly in 11 patients.The frequency and volume of defecation per week increased obviously.Of these 10 patients, permanent implantation of the SNM system was implemented.After a median of 7.8 months(1~20 months)follow-up, defecation frequency increased from(0.80±0.42)to(8.10±2.47)evacuations per week(P<0.01). There was a decrease in time spent toileting from(21.10±10.06)to(3.70±0.67)mins(P<0.01). Cleveland clinic constipation score decreased from(21.10±4.99)to(8.90±0.88)(P<0.01). Visual analogue scale(VAS)score increased from(9.90±3.28)to(84.10±4.63)(P<0.01).

SNM is a clinically efficacious, reversible, minimal invasive and safe technique, and it offers an alternative treatment for the patients with intractable constipation resistant to conservative treatment.