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Chinese Journal of Colorectal Diseases(Electronic Edition) ›› 2025, Vol. 14 ›› Issue (02): 136-141. doi: 10.3877/cma.j.issn.2095-3224.2025.02.004

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FMT in microbiota-gut-brain axis disorders:therapeutic advances

Junfu Chen1,2, Jixia Wu1, Hongliang Tian1,2, Jing Ma1,()   

  1. 1. Department of Neurology,Bengbu First People's Hospital,Bengbu 233000,China
    2. Tongji University School of Medicine,Shanghai 200072,China
  • Received:2024-11-08 Online:2025-04-25 Published:2025-05-12
  • Contact: Jing Ma

Abstract:

The intestine is known as the “second brain” of humans. There is a vicious cycle of mutual causality between intestinal and brain functions,and intestinal diseases are often accompanied by central nervous system degenerative diseases and mental and psychological disorders. The most important intermediate mediator is the intestinal flora. Abnormalities in the intestinal flora can not only directly lead to intestinal dysfunction,but also affect the function of the central nervous system through immune regulation and the synthesis and release of neurotransmitters. Abnormalities in the intestine and central nervous system can further lead to disorders in the intestinal flora. As a means of artificial regulation of the gut microbiota,fecal microbiota transplantation(FMT) is garnering increasing attention in the treatment of diseases related to the microbiota-gut-brain axis.

Key words: Intestinal flora, Microbiota-gut-brain axis, Fecal microbiota transplantation

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