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Chinese Journal of Colorectal Diseases(Electronic Edition) ›› 2025, Vol. 14 ›› Issue (01): 40-46. doi: 10.3877/cma.j.issn.2095-3224.2025.01.004

• Forum for Expert • Previous Articles     Next Articles

Current situation and prospect of liver metastasis research model for colorectal cancer

Jiaying Yuan1, Xiaoyu Fan2,3, Bo Fei1, Chunzhao Yu1,3,()   

  1. 1. Department of General Surgery, Sir Run Run Hospital, Nanjing Medical University, Nanjing 211112, China
    2. Department of General Surgery, Nantong Tongzhou People's Hospital, Nantong 226300, China
    3. Department of General Surgery, the Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China
  • Received:2024-07-24 Online:2025-02-25 Published:2025-03-11
  • Contact: Chunzhao Yu

Abstract:

Colorectal cancer liver metastasis (CRLM) is the most important cause of death in colorectal cancer patients, which seriously threatens the life safety of people and hinders the prosperity and development of society and economy.With the increasing incidence of colorectal cancer in our country,the harm of CRLM is becoming more and more obvious.In this context, how to establish a scientific and effective CRLM model to promote the in-depth understanding of the tumor invasion and metastasis process,reveal the corresponding mechanism, evaluate the effect of different diagnosis and treatment schemes, and finally realize the early prevention and treatment of CRLM should be the focus and difficulty of current research.Traditional CRLM models include carcinogen induction model, orthotopic model, heterotopic model,xenogenic implantation model and genetically engineered mouse model.In recent years, with the continuous progress of science and technology, new modeling methods such as microfluidic chip model have emerged,providing more updating options.In this paper, relevant literature at home and abroad was reviewed, and the advantages and disadvantages of traditional mouse models and emerging modeling methods were discussed in depth, aiming to compare the advantages and disadvantages of each modeling method and introduce the latest research results, so as to provide certain guidance for the scientific establishment of CRLM model and ultimately bring more scientific personalized treatment for CRLM patients.

Key words: Colorectal neoplasms, Liver metastasis, Animal model, Microfluidic Device

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