Home    中文  
 
  • Search
  • lucene Search
  • Citation
  • Fig/Tab
  • Adv Search
Just Accepted  |  Current Issue  |  Archive  |  Featured Articles  |  Most Read  |  Most Download  |  Most Cited

Chinese Journal of Colorectal Diseases(Electronic Edition) ›› 2025, Vol. 14 ›› Issue (01): 47-52. doi: 10.3877/cma.j.issn.2095-3224.2025.01.005

• Forum for Young Expert • Previous Articles     Next Articles

Advancements in the utilization of colorectal cancer organoids for investigating traditional Chinese medicine and its bioactive constituents

Ying Chen1, Yi Wang2,(), Lu Wang3, Desong Kong3, Yang Zhang2, Zhimin Fan3   

  1. 1. Department of Health Policy Research, Jiangsu Health Development Research Center, Nanjing 210036, China
    2. Colon and Rectal Surgery, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing 210022, China
    3. Jiangsu Clinical Innovation Center for Anorectal Diseases of TCM, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing 210022, China
  • Received:2024-08-30 Online:2025-02-25 Published:2025-03-11
  • Contact: Yi Wang

Abstract:

The investigation into the mechanism of action of traditional Chinese medicine and its bioactive components against colorectal cancer primarily relies on in vitro colorectal cancer cell lines and related xenograft animal models.However, organoid has emerged as a potent alternative method that can faithfully recapitulate the genetic characteristics of donors and predict treatment efficacy for individual patients.In this review, we summarize the current literature on the application of colorectal cancer organoids in traditional Chinese medicine research, highlighting their unique value in advancing basic research and providing a solid theoretical foundation for broader clinical implementation of traditional Chinese medicine in treating colorectal cancer.

Key words: Colorectal neoplasms, Organoids, Traditional Chinese Medicine, Review

京ICP 备07035254号-20
Copyright © Chinese Journal of Colorectal Diseases(Electronic Edition), All Rights Reserved.
Tel: 0086-010-87788026 E-mail: cjcd_editor@vip.163.com
Powered by Beijing Magtech Co. Ltd