Diet, gut microbiota and colorectal cancer

doi:10.3877/cma.j.issn.2095-3224.2019.06.001

Abstract

Abstract:

Colorectal cancer (CRC) is one of the most common cancer worldwide, especially in the western countries. Diet is one of the most important factors associated with CRC. Accumulating evidence suggests that diet could re-shape the human gut microbiota and contribute to the development of CRC, not only via the pro-tumorigenic activities of specific pathogens but also via the influence of metabolism and function of the whole microbial community, particularly its metabolites. Recent data have shown that short-chain fatty acids, especially butyrate, could suppress inflammation and anti-cancer, whereas other microbial metabolites, such as secondary bile acids, promote colorectal tumorigenesis. In this Review, we discuss the influence of diet on gut microbiota and its metabolites, the interaction between gut microbiota and CRC, and dietary strategies for CRC prevention. More mechanism studies are warranted to further investigate the interplay of gut microbiota with metabolome, immunity and host response.

Key words: Colorectal neoplasms, Diet, Gut microbiota, Metabolites

Jia Yang, Jun Yu. Diet, gut microbiota and colorectal cancer[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2019, 08(06): 541-545.

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References 41

[1]	Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018 [J]. CA Cancer J Clin, 2018, 68(1): 7-30.
[2]	O′Keefe SJ. Diet, microorganisms and their metabolites, and colon cancer [J]. Nature Reviews Gastroenterology & Hepatology, 2016, 13(12): 691-706.
[3]	Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J].CA Cancer J Clin, 2018, 68(6): 394-424.
[4]	Xu ZJ, Knight R. Dietary effects on human gut microbiome diversity [J]. Br J Nutr, 2015, 113(S1): 51-55.
[5]	Liang Q, Chiu J, Chen Y, et al. Fecal bacteria act as novel biomarkers for noninvasive diagnosis of colorectal cancer [J]. Clin Cancer Res, 2017, 23(8): 2061-2070.
[6]	Hollister EB, Gao C, Versalovic J. Compositional and functional features of the gastrointestinal microbiome and their effects on human health [J]. Gastroenterology, 2014, 146(6): 1449-1458.
[7]	Turnbaugh PJ, Bäckhed F, Fulton L, et al. Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome [J].Cell Host Microbe, 2008, 3(4): 213-223.
[8]	Turnbaugh PJ, Ridaura VK, Faith JJ, et al. The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice [J]. Sci Transl Med, 2009, 1(6): 6ra14.
[9]	David LA, Maurice CF, Carmody RN, et al. Diet rapidly and reproducibly alters the human gut microbiome [J]. Nature, 2014, 505(7484): 559-563.
[10]	O′Keefe SJ, Li JV, Lahti L, et al. Fat, fibre and cancer risk in African Americans and rural Africans[J].Nat Commun, 2015, 6: 6342.
[11]	Zimmer J, Lange B, Frick JS, et al. A vegan or vegetarian diet substantially alters the human colonic faecal microbiota [J]. Eur J Clin Nutr, 2012, 66(1): 53-60.
[12]	De Filippo C, Cavalieri D, Di Paola M, et al. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa [J]. Proc Natl Acad Sci USA, 2010, 107(33): 14691-14696.
[13]	Ou J, Carbonero F, Zoetendal EG, et al. Diet, microbiota, and microbial metabolites in colon cancer risk in rural Africans and African Americans [J]. Am J Clin Nutr, 2013, 98(1): 111-120.
[14]	Silvester KR, Cummings JH. Cummings, does digestibility of meat protein help explain large-bowel cancer risk [J]. Nutrition and Cancer-an International Journal, 1995, 24(3): 279-288.
[15]	Beaumont M, Portune KJ, Steuer N, et al. Quantity and source of dietary protein influence metabolite production by gut microbiota and rectal mucosa gene expression: a randomized, parallel, double-blind trial in overweight humans [J]. Am J Clin Nutr, 2017, 106(4): 1005-1019.
[16]	Windey K, De Preter V, Verbeke K. Relevance of protein fermentation to gut health [J]. Mol Nutr Food Res, 2012, 56(1): 184-196.
[17]	Taira T, Yamaguchi S, Takahashi A, et al. Dietary polyphenols increase fecal mucin and immunoglobulin A and ameliorate the disturbance in gut microbiota caused by a high fat diet [J]. J Clin Biochem Nutr, 2015, 57(3): 212-216.
[18]	Higashimura Y, Naito Y, Takagi T, et al. Protective effect of agaro-oligosaccharides on gut dysbiosis and colon tumorigenesis in high-fat diet-fed mice [J]. Am J Physiol Gastrointest Liver Physiol, 2016, 310(6): G367-375.
[19]	Wan Y, Wang F, Yuan J, et al. Effects of dietary fat on gut microbiota and faecal metabolites, and their relationship with cardiometabolic risk factors: a 6-month randomised controlled-feeding trial [J]. Gut, 2019 Feb 19. pii: gutjnl-2018-317609.
[20]	Dove WF, Clipson L, Gould KA, et al. Intestinal neoplasia in the ApcMin mouse: independence from the microbial and natural killer (beige locus) status [J]. Cancer Res, 1997, 57(5): 812-814.
[21]	Kostic AD, Chun E, Robertson L, et al. Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-Immune microenvironment [J]. Cell Host & Microbe, 2013, 14(2): 207-215.
[22]	Rubinstein MR, Wang X, Liu W, et al. Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/beta-catenin signaling via its FadA adhesin [J]. Cell Host & Microbe, 2013, 14(2): 195-206.
[23]	Bultman SJ. Emerging roles of the microbiome in cancer [J].Carcinogenesis, 2014, 35(2): 249-255.
[24]	Burns MB, Lynch J, Starr TK, et al. Virulence genes are a signature of the microbiome in the colorectal tumor microenvironment [J]. Genome Medicine, 2015, 7(1): 55.
[25]	Arthur JC, Perez-Chanona E, Mühlbauer M, et al. Intestinal inflammation targets cancer-inducing activity of the microbiota [J]. Science, 2012, 338(6103): 120-123.
[26]	Grivennikov SI, Wang K, Mucida D, et al. Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth [J]. Nature, 2012, 491(7423): 254-258.
[27]	Toprak NU, Yagci A, Gulluoglu BM, et al. A possible role of Bacteroides fragilis enterotoxin in the aetiology of colorectal cancer [J]. Clinical Microbiology and Infection, 2006, 12(8): 782-786.
[28]	Uronis JM, Mühlbauer M, Herfarth HH,et al. Modulation of the intestinal microbiota alters colitis-associated Colorectal Cancer Susceptibility [J]. PloS One, 2009, 4(6): e6026.
[29]	Wu S, Rhee KJ, Albesiano E, et al. A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses [J]. Nature Medicine, 2009, 15(9): 1016-1022.
[30]	Wong SH, Kwong TNY, Chow TC, et al. Quantitation of faecal Fusobacterium improves faecal immunochemical test in detecting advanced colorectal neoplasia [J]. Gut, 2017, 66(8): 1441-1448.
[31]	Tsoi H, Chu ESH, Zhang X, et al. Peptostreptococcus anaerobius induces intracellular cholesterol biosynthesis in colon cells to induce proliferation and causes dysplasia in mice [J]. Gastroenterology, 2017, 152(6): 1419-1433.
[32]	Sokol SY. Wnt signaling and dorso-ventral axis specification in vertebrates [J]. Current Opinion in GeNETsics & Development, 1999, 9(4): 405-410.
[33]	Sears CL. Enterotoxigenic bacteroides fragilis: a rogue among symbiotes [J]. Clinical Microbiology Reviews, 2009, 22(2): 349-369.
[34]	Shiryaev SA, Remacle AG, Chernov AV, et al. Substrate cleavage profiling suggests a distinct function of bacteroides fragilis metalloproteinases (fragilysin and metalloproteinase II) at the microbiome-inflammation-cancer interface [J]. Journal of Biological Chemistry, 2013, 288(48): 34956-34967.
[35]	Xinqiang W, Yuanbing W, Liangmei H, et al. Effects of the intestinal microbial metabolite butyrate on the development of colorectal cancer [J]. J Cancer, 2018, 9(14): 2510-2517.
[36]	Cao H, Xu M, Dong W, et al. Secondary bile acid-induced dysbiosis promotes intestinal carcinogenesis [J]. Int J Cancer, 2017, 140(11): 2545-2556.
[37]	Tayyem RF, Bawadi HA, Shehadah I, et al. Dietary patterns and colorectal cancer [J]. Clin Nutr, 2017, 36(3): 848-852.
[38]	Song M, Wu K, Meyerhardt JA, et al. Fiber intake and survival after colorectal cancer diagnosis [J]. JAMA Oncol, 2018, 4(1): 71-79.
[39]	Mehta M, Shike M. Diet and physical activity in the prevention of colorectal cancer [J]. J Natl Compr Canc NETsw, 2014, 12(12): 1721-1726.
[40]	Yao Y, Suo T, Andersson R, et al. Dietary fibre for the prevention of recurrent colorectal adenomas and carcinomas [J]. Cochrane Database Syst Rev, 2017, 1: CD003430.
[41]	He X, Wu K, Zhang X, et al. Dietary intake of fiber, whole grains and risk of colorectal cancer: An updated analysis according to food sources, tumor location and molecular subtypes in two large US cohorts [J]. Int J Cancer, 2018, 143(2): 298-306.

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