Research progression of the relativity between epithelial-mesenchymal transition and colorectal cancer

doi:10.3877/cma.j.issn.2095-3224.2016.01.13

Abstract

Abstract:

Epithelial mesenchymal transition (EMT), refers to the epithelial cells obtained interstitial cell phenotype under some specific factors, EMT play an important role in the process of malignant tumor occurrence and progress. The invasion and distant metastasis of colorectal cancer cell is closely related to the EMT, EMT may become a new target for inhibiting metastasis of colorectal cancer, and be a new field for tumor treatment.

Key words: Colorectal neoplasms, Research, Progress

Qiang Fei, Yifei Feng, Yueming Sun. Research progression of the relativity between epithelial-mesenchymal transition and colorectal cancer[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2016, 05(01): 64-67.

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References 45

[1]	Greenburg G, Hay ED. Epithelia suspended in collagen gels can lose polarity and express characteristics of migrating mesenchymal cells. J Cell Biol, 1982, 95(1): 333-339.
[2]	Mjaatvedt C H, Markwald RR. Induction of an epithelial-mesenchymal transition by an in vivo adheron-like complex. Dev Biol, 1989, 136(1): 118-128.
[3]	Li L, Li W. Epithelial-mesenchymal transition in human cancer: comprehensive reprogramming of metabolism, epigenetics, and differentiation. Pharmacol Ther, 2015, 150: 33-46.
[4]	Brabletz T, Jung A, Spaderna S, et al. Opinion: migrating cancer stem cells-an integrated concept of malignant tumour progression. Nat Rev Cancer, 2005, 5(9): 744-749.
[5]	Ferlay J, Shin H R, Bray F, et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer, 2010, 127(12): 2893-2917.
[6]	Van Cutsem E, Rivera F, Berry S, et al. Safety and efficacy of first-line bevacizumab with FOLFOX, XELOX, FOLFIRI and fluoropyrimidines in metastatic colorectal cancer: the BEAT study. Ann Oncol, 2009, 20(11): 1842-1847.
[7]	Brenner H, Kloor M, Pox C P. Colorectal cancer. Lancet, 2014, 383(9927): 1490-1502.
[8]	Tepass U, Truong K, Godt D, et al. Cadherins in embryonic and neural morphogenesis. Nat Rev Mol Cell Biol, 2000, 1(2): 91-100.
[9]	Shargh S A, Sakizli M, Khalaj V, et al. Downregulation of E-cadherin expression in breast cancer by promoter hypermethylation and its relation with progression and prognosis of tumor. Med Oncol, 2014, 31(11): 250.
[10]	Pena C, Garcia J M, Silva J, et al. E-cadherin and vitamin D receptor regulation by SNAIL and ZEB1 in colon cancer: clinicopathological correlations. Hum Mol Genet, 2005, 14(22): 3361-3370.
[11]	He X, Chen Z, Jia M, et al. Downregulated E-cadherin expression indicates worse prognosis in Asian patients with colorectal cancer: evidence from meta-analysis. PLoS One, 2013, 8(7): e70858.
[12]	韩婧，潘燕，李学军．波形蛋白的结构、功能和与肿瘤的关系．医学分子生物学杂志，2011，08(3): 265-268.
[13]	Singh S, Sadacharan S, Su S, et al. Overexpression of vimentin: role in the invasive phenotype in an androgen-independent model of prostate cancer. Cancer Res, 2003, 63(9): 2306-2311.
[14]	Cao H, Xu E, Liu H, et al. Epithelial-mesenchymal transition in colorectal cancer metastasis: A system review. Pathol Res Pract, 2015, 211(8): 557-569.
[15]	Massague J. How cells read TGF-beta signals. Nat Rev Mol Cell Biol, 2000, 1(3): 169-178.
[16]	Shi Y, Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell, 2003, 113(6): 685-700.
[17]	Brown K A, Pietenpol J A, Moses H L. A tale of two proteins: differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling. J Cell Biochem, 2007, 101(1): 9-33.
[18]	Vincan E, Barker N. The upstream components of the Wnt signalling pathway in the dynamic EMT and MET associated with colorectal cancer progression. Clin Exp Metastasis, 2008, 25(6): 657-663.
[19]	Arend R C, Londono-Joshi A I, Straughn J J, et al. The Wnt/beta-catenin pathway in ovarian cancer: a review. Gynecol Oncol, 2013, 131(3): 772-779.
[20]	Cho S W, Kim Y A, Sun H J, et al. Therapeutic potential of Dickkopf-1 in wild-type BRAF papillary thyroid cancer via regulation of beta-catenin/E-cadherin signaling. J Clin Endocrinol Metab, 2014, 99(9): E1641-E1649.
[21]	Qi L, Sun B, Liu Z, et al. Dickkopf-1 inhibits epithelial-mesenchymal transition of colon cancer cells and contributes to colon cancer suppression. Cancer Sci, 2012, 103(4): 828-835.
[22]	Wang Y, Ngo V N, Marani M, et al. Critical role for transcriptional repressor Snail2 in transformation by oncogenic RAS in colorectal carcinoma cells. Oncogene, 2010, 29(33): 4658-4670.
[23]	Suman S, Kurisetty V, Das T P, et al. Activation of AKT signaling promotes epithelial-mesenchymal transition and tumor growth in colorectal cancer cells. Mol Carcinog, 2014, 53(Suppl 1): E151-E160.
[24]	Katoh M, Katoh M. Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL signaling cascades. Cancer Biol Ther, 2006, 5(9): 1059-1064.
[25]	全天一，李伟明，朱秋玲，等．miR-145下调与结直肠癌上皮间叶转化的分子机制探讨．中国现代普通外科进展，2013，16(8): 589-593.
[26]	Park S M, Gaur A B, Lengyel E, et al. The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev, 2008, 22(7): 894-907.
[27]	Siemens H, Neumann J, Jac kstadt R, et al. Detection of miR-34a promoter methylation in combination with elevated expression of c-Met and beta-catenin predicts distant metastasis of colon cancer. Clin Cancer Res, 2013, 19(3): 710-720.
[28]	Herrera M, Islam A B, Herrera A, et al. Functional heterogeneity of cancer-associated fibroblasts from human colon tumors shows specific prognostic gene expression signature. Clin Cancer Res, 2013, 19(21): 5914-5926.
[29]	任春霞，赵敏，徐娜，等．癌相关成纤维细胞通过IL-6诱导的"上皮-间质"转换促进宫颈癌细胞的迁移和侵袭．中国癌症杂志，2014(4): 252-257.
[30]	Miyoshi A, Kitajima Y, Sumi K, et al. Snail and SIP1 increase cancer invasion by upregulating MMP family in hepatocellular carcinoma cells. Br J Cancer, 2004, 90(6): 1265-1273.
[31]	Savagner P. Leaving the neighborhood: molecular mechanisms involved during epithelial-mesenchymal transition. Bioessays, 2001, 23(10): 912-923.
[32]	Wang H, Wang H S, Zhou B H, et al. Epithelial-mesenchymal transition (EMT) induced by TNF-alpha requires AKT/GSK-3 beta-mediated stabilization of snail in colorectal cancer. PLoS One, 2013, 8(2): e56664.
[33]	Hwang W L, Yang M H, Tsai M L, et al. SNAIL regulates interleukin-8 expression, stem cell-like activity, and tumorigenicity of human colorectal carcinoma cells. Gastroenterology, 2011, 141(1): 279-291.
[34]	Tam W L, Weinberg R A. The epigenetics of epithelial-mesenchymal plasticity in cancer. Nat Med, 2013, 19(11): 1438-1449.
[35]	Moen I, Oyan A M, Kalland K H, et al. Hyperoxic treatment induces mesenchymal-to-epithelial transition in a rat adenocarcinoma model. PLoS One, 2009, 4(7): e6381.
[36]	Zeisberg M, Neilson E G. Biomarkers for epithelial-mesenchymal transitions. J Clin Invest, 2009, 119(6): 1429-1437.
[37]	Hongo K, Tsuno N H, Kawai K, et al. Hypoxia enhances colon cancer migration and invasion through promotion of epithelial-mesenchymal transition. J Surg Res, 2013, 182(1): 75-84.
[38]	Yang A D, Fan F, Camp E R, et al. Chronic oxaliplatin resistance induces epithelial-to-mesenchymal transition in colorectal cancer cell lines. Clin Cancer Res, 2006, 12(14 Pt 1): 4147-4153.
[39]	Kajiyama H, Shibata K, Terauchi M, et al. Chemoresistance to paclitaxel induces epithelial-mesenchymal transition and enhances metastatic potential for epithelial ovarian carcinoma cells. Int J Oncol, 2007, 31(2): 277-283.
[40]	Hoshino H, Miyoshi N, Nagai K, et al. Epithelial-mesenchymal transition with expression of SNAI1-induced chemoresistance in colorectal cancer. Biochem Biophys Res Commun, 2009, 390(3): 1061-1065.
[41]	Findlay V J, Moretz R E, Wang C, et al. Slug expression inhibits calcitriol-mediated sensitivity to radiation in colorectal cancer. Mol Carcinog, 2014, 53(Suppl 1): E130-E139.
[42]	Brabletz T, Jung A, Spaderna S, et al. Opinion: migrating cancer stem cells-an integrated concept of malignant tumour progression. Nat Rev Cancer, 2005, 5(9): 744-749.
[43]	Matsunaga K, Hosokawa A, Oohara M, et al. Direct action of a protein-bound polysaccharide, PSK, on transforming growth factor-beta. Immunopharmacology, 1998, 40(3): 219-230.
[44]	Sakamoto J, Morita S, Oba K, et al. Efficacy of adjuvant immunochemotherapy with polysaccharide K for patients with curatively resected colorectal cancer: a meta-analysis of centrally randomized controlled clinical trials. Cancer Immunol Immunother, 2006, 55(4): 404-411.
[45]	Olmeda D, Jorda M, Peinado H, et al. Snail silencing effectively suppresses tumour growth and invasiveness. Oncogene, 2007, 26(13): 1862-1874.

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