Expression of stathmin and cathepsin B in colorectal cancer

doi:10.3877/cma.j.issn.2095-3224.2015.01.10

Abstract

Abstract:

Objective

To investigate the differential expression of Stathmin and Cathepsin B in human colorectal cancer tissues and related metastatic foci and its clinicopathological significance.

Methods

Immunohistochemical staining for Stathmin and Cathepsin B was performed in 158 cases of colorectal cancer tissues and related 64 cases of metastatic foci within the tissue microarray.

Results

Both Stathmin and Cathepsin B are upregulated in colorectal cancer and related metastatic samples(P<0.05 and P<0.01 respectively). The location of Stathmin and Cathepsin B transferred from cytoplasm to nuclear in low differentiation colorectal cancer samples compared with high to mediate differentiation samples.

Conclusion

Stathmin and Cathepsin B may be valuable biomarkers for clinical differentiation of colorectal cancer.

Key words: Colorectal neoplasms, Stathmin, Cathepsin B

Zheng-duo YANG, Dan ZHANG, Hong-cheng LV, Li ZHANG, Guang LIU, Hui MA, Gang WANG, Shi-wu ZHANG. Expression of stathmin and cathepsin B in colorectal cancer[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2015, 04(01): 45-49.

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References 22

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