USP22 and its potential targets in colorectal adenocarcinoma

doi:10.3877/cma.j.issn.2095-3224.2014.01.06

Abstract

Abstract:

Objective

To investigate the expression of USP22 and its potential targets in colorectal carcinoma.

Methods

82 cases of colorectal carcinoma were examined by quantitative RT-PCR.

Results

Statistical correlation analysis in mRNA level shown that USP22 was strongly correlated with BMI-1(r=0.790, P<0.0001), c-Myc(r=0.528, P<0.0001)and cyclin D2(r=0.657, P<0.0001), but not correlated with p16INK4a(r=0.103, P=0.358)or p14ARF(r=-0.039, P=0.731).

Conclusion

USP22 may activate BMI1 oncogene-driven pathway signature such as INK4a/ARF or Akt signature via activating the c-Myc-targeted genes such as cyclinD2, which may act as important role in tumor progression.

Key words: USP22, Colorectal cancer, Metastasis

Zheng JIANG, Yan-long LIU, Xi-shan WANG. USP22 and its potential targets in colorectal adenocarcinoma[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2014, 03(01): 24-27.

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?		Log10USP22	Log10BMI-1	Log10c-Myc	Log10cyclin D2	Log10p16INK4a	Log10p14ARF
Log10USP22		?	?	?	?	?	?
?	Pearson Correlation	?	0.790^a	0.528^a	0.657^a	0.103	0.039
?	Sig.(2-tailed)	?	0.000	0.000	0.000	0.358	0.731
Log10BMI-1		?	?	?	?	?	?
?	Pearson Correlation	?	?	0.558^a	0.748^a	0.159	0.197
?	Sig.(2-tailed)	?	?	0.000	0.000	0.154	0.076
Log10c-Myc		?	?	?	?	?	?
?	Pearson Correlation	?	?	?	0.666^a	0.269^b	0.155
?	Sig.(2-tailed)	?	?	?	0.000	0.015	0.164
Log10cyclin D2		?	?	?	?	?	?
?	Pearson Correlation	?	?	?	?	0.290^a	0.164
?	Sig.(2-tailed)	?	?	?	?	0.008	0.141
Log10p16INK4a		?	?	?	?	?	?
?	Pearson Correlation	?	?	?	?	?	0.058
?	Sig.(2-tailed)	?	?	?	?	?	0.607
Log10p14ARF		?	?	?	?	?	?
?	Pearson Correlation	?	?	?	?	?	?
?	Sig.(2-tailed)	?	?	?	?	?	?

?		Log10USP22	Log10BMI-1	Log10c-Myc	Log10cyclin D2	Log10p16INK4a	Log10p14ARF
Log10USP22		?	?	?	?	?	?
?	Pearson Correlation	?	0.790^a	0.528^a	0.657^a	0.103	0.039
?	Sig.(2-tailed)	?	0.000	0.000	0.000	0.358	0.731
Log10BMI-1		?	?	?	?	?	?
?	Pearson Correlation	?	?	0.558^a	0.748^a	0.159	0.197
?	Sig.(2-tailed)	?	?	0.000	0.000	0.154	0.076
Log10c-Myc		?	?	?	?	?	?
?	Pearson Correlation	?	?	?	0.666^a	0.269^b	0.155
?	Sig.(2-tailed)	?	?	?	0.000	0.015	0.164
Log10cyclin D2		?	?	?	?	?	?
?	Pearson Correlation	?	?	?	?	0.290^a	0.164
?	Sig.(2-tailed)	?	?	?	?	0.008	0.141
Log10p16INK4a		?	?	?	?	?	?
?	Pearson Correlation	?	?	?	?	?	0.058
?	Sig.(2-tailed)	?	?	?	?	?	0.607
Log10p14ARF		?	?	?	?	?	?
?	Pearson Correlation	?	?	?	?	?	?
?	Sig.(2-tailed)	?	?	?	?	?	?

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