Expression and significance of IL-6 in rat colon tissue with ulcerative colitis

doi:10.3877/cma.j.issn.2095-3224.2014.01.07

Chinese Journal of Colorectal Diseases(Electronic Edition) ›› 2014, Vol. 03 ›› Issue (01): 28-29. doi: 10.3877/cma.j.issn.2095-3224.2014.01.07

Special Issue: ；

• Original Article • Previous Articles Next Articles

Expression and significance of IL-6 in rat colon tissue with ulcerative colitis

Yu-jing FAN¹, Feng-hua PEI¹, Ji-tao SONG¹, Bing-rong LIU¹^,^†()

^1. Department of Gastroenterology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China

Received:2014-01-12 Online:2014-02-25 Published:2014-02-25
Contact: Bing-rong LIU
About author:
Corresponding author: LIU Bing-rong, Email: liubingrong@medmail.com.cn

Abstract

Abstract:

Objective

To explore the expression of IL-6 in rat colon tissue with ulcerative colitis.

Methods

Thirty SD rats were randomly divided into control group(10 rats)and model group(20 rats). The model group were induced by trinitrobenzene sulfonic acid and ethanol.The expression of IL-6 in colonic mucosa in two groups were measured with ELISA.

Results

The level of IL-6 was significantly higher in UC group than the controls.

Conclusion

IL-6 is closely related with UC and play an important role in the inflammatory progress of this disease.

Key words: Colitis ulcerative, Interleukin, ELISA

Yu-jing FAN, Feng-hua PEI, Ji-tao SONG, Bing-rong LIU. Expression and significance of IL-6 in rat colon tissue with ulcerative colitis[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2014, 03(01): 28-29.

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组别	N	IL-6(ng/L)	t	P
对照组	10	20.49±4.80	2.671	0.006
UC组	20	39.45±2.61	2.671	0.006

组别	N	IL-6(ng/L)	t	P
对照组	10	20.49±4.80	2.671	0.006
UC组	20	39.45±2.61	2.671	0.006

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