Investigate the safety of abdominal local administration of pseudomonas aeruginosa preparation during operation of colorectal cancer.And observe the therapeutic effect after operation.

119 patients with colorectal cancer taking operation alone in our hospital were selected as control.96 patients which were treated by pseudomonas aeruginosa preparation in abdominal cavity during operation were chosen as the intervention group.Investigate the change of body temperature, recovery rate of the intestinal functions, peritoneal drainage volum after operation.Chose the patients in Dukes C and Dukes D stage among the two groups to follow up and took retrospective analysis.

Observed and recorded the incidence of adverse reaction within 3 days after operation.Incidence rate of body temperature over 37.5℃: control group was 54.62% while the intervention group was 56.25%(P>0.05). Recovery of the intestinal functions: control group was 49.59% and the treated group was 51.04%.Volume of peritoneal drainage more than 50 ml: control group was 18.49% compared with treated group was 16.67%.Growth of white blood cell: control group was 26.05% and treated group was26.04%.Survival curve analysis showed that median survival time of the treatment group was higher than control group(P>0.05)for stage III, IV patients.For patients in stage III, 3 year-survival-rate and 5-year-survival-rate of treatment group were 68.3%/39.0% compared with control group which were 51.1%/25.5%(P>0.05). For patients in stage IV, there was no significantly difference between the two groups in survival rates.

The treatment of pseudomonas aeruginosa preparation administrated in abdominal cavity is safe and feasible.But it does not have significant effect on long-term survival rate.