Expression and significance of B-cell specific moloney leukemia virus insertion site 1 in colorectal ovarian metastasis

doi:10.3877/cma.j.issn.2095-3224.2012.01.05

Abstract

Abstract:

Objective

This study aims at understanding the role of Bim-1 in the clinicopathological features of colorectal cancer and the progression of ovarian metastasis.

Methods

Normal intestinal mucosa, primary lesion of colorectal carcinoma and metastatic ovarian were obtained from the Third Affiliated Hospital of Harbin Medical University in April 2010 to July 2011. Immunohistochemical staining of Bmi-1 was carried out in 44 cases with colorectal carcinoma, including primary lesion the metastatic ovarian and normal intestinal mucosa.T.test or χ² test was used to statistically analysized the results.

Results

The rate in primary lesion was significantly higher than that in normal intestinal mucosa (65.9%, 15.9%, χ²=22.752, P<0.01). Bmi-1 expression in primary lesion was significantly correlated with differentiation, TNM stage and lymphatic metastasis(χ²=5.116, P=0.024; χ²=4.856, P=0.028; χ²=5.495, P=0.019). These was no overexpressed in ovarian metastasis. Overexpression of Bmi-1 protein was significantly correlated with tumorigenesis and progression of colorectal cancer. Although Bmi-1 has no overexpression in ovarian metastasis, those patients with overexpression of Bmi-1 have a short survival (13.16 months, 16.87 months t=-2.524, P=0.012).

Conclusions

Overexpression of Bmi-1 is significantly correlated with prognosis of colorectal cancer with ovarian metastasis.Bmi-1 might be regarded as an important prognostic factor of CRC.

Key words: Colorectal neoplasme, Neoplasm metastasis, Ovary

Jing-wen LI, Xi-shan WANG. Expression and significance of B-cell specific moloney leukemia virus insertion site 1 in colorectal ovarian metastasis[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2012, 01(01): 22-25.

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References 16

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项目		例数	Bmi-1(例)		χ²值	P值
项目		例数	阴性	阳性	χ²值	P值
年龄^a		?	?	?	0.03	1.000
?	<60岁	33	11	22	?	?
?	≥60岁	11	4	7	?	?
是否绝经		?	?	?	1.349	0.246
?	已绝经	20	5	15	?	?
?	未绝经	24	10	14	?	?
肿瘤位置		?	?	?	0.271	0.063
?	结肠	26	7	19	?	?
?	直肠	18	8	10	?	?
肿瘤大小		?	?	?	0.024	0.877
?	<5 cm	14	5	9	?	?
?	≥5 cm	30	10	20	?	?
肿瘤生长特性		?	?	?	6.246	0.012
?	非浸润性	18	10	8	?	?
?	浸润性	26	5	21	?	?
肿瘤分化程度		?	?	?	5.116	0.024
?	较好	19	10	9	?	?
?	较差	25	5	20	?	?
术前T分期		?	?	?	4.856	0.028
?	T1，T2，T3	14	8	6	?	?
?	T4	30	7	23	?	?
术前N分期		?	?	?	5.495	0.019
?	NO	16	9	7	?	?
?	N1，N2	28	6	22	?	?
卵巢转移时间		?	?	?	0.004	0.951
?	同时性	16	5	11	?	?
?	异时性	28	9	19	?	?

项目		例数	Bmi-1(例)		χ²值	P值
项目		例数	阴性	阳性	χ²值	P值
年龄^a		?	?	?	0.03	1.000
?	<60岁	33	11	22	?	?
?	≥60岁	11	4	7	?	?
是否绝经		?	?	?	1.349	0.246
?	已绝经	20	5	15	?	?
?	未绝经	24	10	14	?	?
肿瘤位置		?	?	?	0.271	0.063
?	结肠	26	7	19	?	?
?	直肠	18	8	10	?	?
肿瘤大小		?	?	?	0.024	0.877
?	<5 cm	14	5	9	?	?
?	≥5 cm	30	10	20	?	?
肿瘤生长特性		?	?	?	6.246	0.012
?	非浸润性	18	10	8	?	?
?	浸润性	26	5	21	?	?
肿瘤分化程度		?	?	?	5.116	0.024
?	较好	19	10	9	?	?
?	较差	25	5	20	?	?
术前T分期		?	?	?	4.856	0.028
?	T1，T2，T3	14	8	6	?	?
?	T4	30	7	23	?	?
术前N分期		?	?	?	5.495	0.019
?	NO	16	9	7	?	?
?	N1，N2	28	6	22	?	?
卵巢转移时间		?	?	?	0.004	0.951
?	同时性	16	5	11	?	?
?	异时性	28	9	19	?	?

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