To study the expression and prognosis of high mobility group protein B1 (HMGB1) gene in colon tumor.

The HMGB1-related data of 2 191 colon tumor patients were mined from Oncomine and TCGA datasets. The Mann-Whitney U test was used to compare the differential expression of HMGB1 between colonic adenoma and carcinoma, left and right half colon cancer, carcinoma in situ and infiltrating cancer, mucinous adenocarcinoma and other pathological types, with lymph node metastasis and without lymph node metastasis, with distant metastasis and without distant metastasis of colon cancer. Then the Kaplan Meier survival curve was drawn.

HMGB1 gene was highly expressed in colon cancer tissues and adenoma tissues than in normal colon tissues (P<0.001), higher in colon cancer tissues than in colonic adenoma tissues, overexpressed in left colon cancer compared to right colon cancer (P<0.05), lower in mucinous adenocarcinoma of the colon than other pathological tissue types (P<0.05), overexpressed in infiltrating carcinoma compared with carcinoma in situ (P<0.001), overexpressed in patients with regional lymph node metastasis (P<0.05), and overexpressed in metastatic colon cancer than non-metastatic colon cancer (P<0.05). Overexpression of HMGB1 gene indicates a higher 5-year survival rate (P=0.011), especially for female patients (P=0.006).

HMGB1 gene can be used as a marker to evaluate the invasion depth, lymphatic metastasis, distant metastasis and prognosis of colon cancer.

To investigate the causes and influencing factors of unplanned reoperation patients in the colorectal neoplasms.

A retrospective analysis was conducted on the clinical data of the colorectal neoplasms surgical patients of Cancer Hospital Chinese Academy of Medical Sciences from January 1, 2014 to December 31, 2019.

Among 10 761 cases of colorectal neoplasms, 132 cases underwent unplanned reoperation, with an incidence of 1.23%. Unplanned reoperation mainly occurred three days after the surgery. The main causes were anastomotic leakage (50.00%), intestinal obstruction (17.42%), peristomial complication (12.12%) and bleeding (9.85%). Multivariate logistic regression analysis revealed that male (OR=2.32; 95% CI: 1.53~3.52; P<0.001), colorectal cancer patients (OR=2.87; 95% CI: 1.86~4.45; P<0.001) and patients with history of surgery (OR=2.98; 95% CI: 1.99~4.48; P<0.001) were the independent risk factors of unplanned reoperations. The unplanned reoperation increased the risk of patients transferred to the ICU and death. Unplanned reoperation extended 10.78 days of hospitalization time and increased 42 428.69 RMB in hospitalization expenses.

Unplanned reoperation increases hospital operating costs and patients' burden. We should focus on the patients who were male, with a history of previous surgery, especially whose surgical site were rectum. We should make adequate preoperative of perioperative management to prevent intestinal obstruction, anastomotic fistula, peristomial complication and bleeding.

Explore the auxiliary effect of nursing intervention in the operating room on the rapid postoperative recovery of rectal cancer patients.

A total of 120 patients undergoing radical laparoscopic colorectal cancer surgery who were admitted to the Cancer Hospital of Harbin Medical University from December 2017 to June 2019 were selected and divided into two groups. Sixty cases in each group, the conventional nursing group implemented traditional surgical care, and the special nursing group based on this, carried out comprehensive nursing interventions in the operating room, and then performed a baseline analysis of their basic conditions such as age, gender, and operation time. The time of exhaustion, the time of first meal after surgery, the length of hospitalization and the occurrence of complications.

The special care group was superior to the conventional care group in the time of first postoperative feeding (t=2.739, P=0.009), time of first postoperative exhaust (t=2.237, P=0.026) and postoperative hospital stay (t=2.012, P=0.046), and the difference between the two groups was statistically significant.

For patients undergoing rectal cancer surgery, the implementation of intensive and systematic nursing intervention in the operating room can accelerate the recovery of patients′ gastrointestinal function and shorten the length of hospitalization, which conforms to the concept of rapid rehabilitation and has clinical application value.

This study aims at understanding the role of Bim-1 in the clinicopathological features of colorectal cancer and the progression of ovarian metastasis.

Normal intestinal mucosa, primary lesion of colorectal carcinoma and metastatic ovarian were obtained from the Third Affiliated Hospital of Harbin Medical University in April 2010 to July 2011. Immunohistochemical staining of Bmi-1 was carried out in 44 cases with colorectal carcinoma, including primary lesion the metastatic ovarian and normal intestinal mucosa.T.test or χ² test was used to statistically analysized the results.

The rate in primary lesion was significantly higher than that in normal intestinal mucosa (65.9%, 15.9%, χ²=22.752, P<0.01). Bmi-1 expression in primary lesion was significantly correlated with differentiation, TNM stage and lymphatic metastasis(χ²=5.116, P=0.024; χ²=4.856, P=0.028; χ²=5.495, P=0.019). These was no overexpressed in ovarian metastasis. Overexpression of Bmi-1 protein was significantly correlated with tumorigenesis and progression of colorectal cancer. Although Bmi-1 has no overexpression in ovarian metastasis, those patients with overexpression of Bmi-1 have a short survival (13.16 months, 16.87 months t=-2.524, P=0.012).

Overexpression of Bmi-1 is significantly correlated with prognosis of colorectal cancer with ovarian metastasis.Bmi-1 might be regarded as an important prognostic factor of CRC.