Intussusception caused by intestinal lipoma is rare and prone to be missed and misdiagnosed for its nonspecific clinical symptoms. The diagnosis depends on pathology although CT and endoscopy may be helpful and surgical resection is an effective treatment for intussusception secondary to intestinal lipoma. Two cases of intussusception secondary to intestinal lipoma were treated in the Second Affiliated Hospital of Nanjing Medical University. Two patients underwent surgical treatment and had a good recovery. The clinical manifestations, diagnosis and treatment of intussusception secondary to intestinal lipoma are discussed in order to improve clinicians' recognization.