To investigate the factors influencing the tissue integrity resection rate of 10 mm~20 mm non-metastatic rectal neuroendocrine tumor.

The hospital database data of patients with rectal neuroendocrine tumor admitted to Department of General Surgery and Gastroenterology, Suqian Hospital, Xuzhou Medical University from January 2008 to April 2019 were retrospectively analyzed, and the characteristics of factors were summarized, to compare and analyze the influencing factors of tissue integrity between endoscopic submucosal resection and transanal resection, it will be meaningful to conduct multi-factor analysis to find out the independent risk factors.

Of the 24 patients, the median age of diagnosis was 43 years (29 to 58 years) and 62.5% was male. The median distance from the anal border was 6.2 cm (3 cm~15 cm). The median tumor diameter was 11.7 mm (10 mm~20 mm).Tumor invasion was confined to the mucosal layer in 12 patients (50%), and the submucosal layer in 12 patients. The median follow-up time was 37.3 months (range 3.5~113.0). The complete resection rate was 84.62% in 13 patients. The complete resection rate was 54.55% in 11 cases. There were significant differences between the two groups (χ²=2.542, 2.663; P=0.028, 0.046). For the comparison of the integrity of histological resection, the invasion depth, tumor size, G stage and microscopic performance were the risk factors influencing the resection or not by univariate analysis, and the significant univariate analysis showed that tumor invasion depth and tumor size were the independent risk factors.

For 10 mm~20 mm non-metastatic rectal neuroendocrine tumors, the depth of tumor invasion and tumor size are independent risk factors for complete tissue resection.