This study aims to evaluate the safety and feasibility of side-to-side isoperistaltic anastomosis in segmental colectomy for Crohn's disease patients.

Clinical data, postoperative results and short-term outcomes of follow-up of enrolled CD patients, who underwent segmental colectomy and received side-to-side isoperistaltic anastomosis from January 2017 to December, 2020 were retrospectively collected and analyzed.

Totally six CD patients including 4 male and 2 female patients were enrolled, with an average age of (31.6±1.8) years old. The mean postoperative time was (155±74) min. No anastomotic leak occurred. Median postoperative time was 9 (7~15) days. The rates of readmission, reoperation and mortality were all 0. After a median follow up of 10 (4~18) months, only one endoscopic recurrence was observed among the 5 patients who had completed endoscopic surveillance endoscopic surveillance (one patient was followed up less than six months). There was no clinical or surgical recurrence.

The present study showed that side-to-side isoperistaltic anastomosis is feasible for CD patients who required segmental colectomy. Theoretically, this anastomotic technique has advantages both in reducing short-term complications, e.g. anastomotic leak, and long-term postoperative recurrence.