To summarize the curative effect and functional outcome of patient undergoing transanal ileal pouch anal anastomosis(ta-IPAA).

Eleven patients suffering from ulcerative colitis (UC) or familial adenomatous polyposis (FAP) at Department of Gastroenterological Surgery, Peking University People's Hospital from January 2016 to December 2020 were retrospectively collected. CGQL scale was used to assess quality of life, LARS scale were used to evaluate anal function, IPSS score was used to evaluate urinary function, IIEF-5 and FSFI score were used to evaluate male and female sexual function, respectively. And we analyzed the data related to the operation.

The operative time of ta-IPAA in our center was (324.55±97.51)min, the intraoperative blood loss was (307.27±272.91)mL, and the postoperative hospital stay was 11~43 days (median time was 15 days). A total of eleven complications occurred in six patients in the ta-IPAA group after surgery, including two patients with Clavien-Dindo grade three or above. The postoperative quality of life score CGQL was 0.76±0.14. In terms of defecation function, six patients had no LARS, two had mild LARS and one had severe LARS. In terms of urinary function, IPSS score of one patient was severe, and eight patients were asymptomatic or mild. In terms of sexual function, seven cases were male, one case had no sexual life before surgery, five cases had normal erectile function, and one case had severe erectile dysfunction. Two women had no sex life for nearly 4 weeks and could not be evaluated by FSFI score.

Patients in our unit have good functional recovery after ta-IPAA surgery, and postoperative defecation, urination and sexual function are of good level. But the incidence of postoperative complications is high, and the safety of the operation needs to be further improved. Combined transabdominal and transanal surgery is helpful to shorten the operation time and reduce the difficulty of simple transabdominal low rectal separation, which has a certain application prospect in the surgical treatment of UC, FAP and other diseases requiring total colorectal resection