LncRNA SNHG17 promotes the metastasis of colorectal cancer by inducing epithelial-mesenchymal transition

doi:10.3877/cma.j.issn.2095-3224.2021.04.006

Abstract

Abstract:

Objective

To investigate the role of long non-coding RNA small nucleolar RNA host gene 17 (SNHG17) and its molecular mechanism in colorectal cancer.

Methods

Quantitative Realtime PCR (qRT-PCR) was used to detect the expression of SNHG17 in colon cancer cell lines and normal colon epithelial cells; SNHG17 was overexpressed or silenced by transfection with SNHG17 plasmid or SNHG17-shRNA, to detect its effect on the migration and invasion of colorectal cancer cell lines.

Results

SNHG17 was up-regulated in colorectal cancer tissues and cell lines. The silencing of SNHG17 could inhibit colorectal cancer cell migration and invasion while the up-regulation of SNHG17 promoted colorectal cancer cell migration and invasion.

Conclusion

LncRNA SNHG17 is highly expressed in colorectal cancer and promotes the migration and invasion of colorectal cancer cells by inducing epithelial-mesenchymal transition.

Key words: Colorectal neoplasms, Long non-coding RNA（Lnc RNA）, Small nucleolar RNA host gene 17, Epithelial-mesenchymal transition（EMT）

Changhui Geng, Chunling Zhang, Ping Gao, Miao He, Huifeng Li, Yini Yao, Yingxin Liu. LncRNA SNHG17 promotes the metastasis of colorectal cancer by inducing epithelial-mesenchymal transition[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2021, 10(04): 367-370.

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References 20

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