Research progress of microRNAs regulating colorectal cancer stem cells

doi:10.3877/cma.j.issn.2095-3224.2021.03.015

Abstract

Abstract:

Colorectal cancer stem cells(CCSCs) are a subpopulation of colorectal cancer cells with the potential of self-renewal, proliferation and differentiation, which can initiate and promote the occurrence and progress of colorectal cancer. And it is closely related to the recurrence, metastasis, radiotherapy and chemotherapy resistance of colorectal cancer. MicroRNAs are a kind of small noncoding RNAs, involved in post-transcriptional regulation. A large number of studies have shown that MicroRNAs play an important role in the self-renewal, proliferation, differentiation, drug resistance and other biological processes of colorectal cancer stem cells. Herein we summarized various mechanisms of MicroRNAs regulating the characteristics of colorectal cancer stem cells, especially in a variety of signal pathways. In addition, we introduced the application prospect of MicroRNAs in the diagnosis and treatment of colorectal cancer. Advanced study of the molecular mechanism of MicroRNAs in colorectal cancer stem cells will help us to understand the biological characteristics and behavior of colorectal cancer stem cells better, and will also provide a new reference for clinical treatment of targeted colorectal cancer stem cells.

Key words: Colorectal neoplasms, MicroRNAs, Cancer stem cells

Suwen Ou, Kangjia Luo, Zilong Guan, Rui Huang. Research progress of microRNAs regulating colorectal cancer stem cells[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2021, 10(03): 306-312.

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miRNAs	靶基因	细胞系	功能	参考文献
miR-106a	DUSP2	HCT116、SW620	促进5-Fu耐药	［60］
miR-27a	APAF-1	HT29、SW480	促进TRAIL耐药	［61］
miR-221	QKI-5	HCT116	促进增殖、干性	［62］
miR-17	CYP7B1	DLD1	促进干性、EMT	［63］
miR-106b	CDKN1A（P21）	SW620、SW480	促进辐射抗性	［35］
miR-196b-5p	SOCS1/3	HCT116、SW480	促进干性、化疗耐药	［32］
miR-133b	DOT1L	HT29、HCT116、SW620	抑制干性、化疗耐药	［64］
miR-146b-5p、miR5095p	WBSCR22	DLD1、RKO	抑制干性、化疗耐药	［65, 66］
miR-4711-5p	TFDP1、MDM2	DLD-1、HCT116	诱导G1期阻滞、促进凋亡	［45］
miR-124	PRRX1	SW480、LOVO	抑制干性、放疗抗性	［67］
miR-328	MMP16	SW1116、SW480	抑制干性、耐药、侵袭	［57］
miR-203	IL-8	HCT-116、HT-29	抑制干性	［43］
miR-200b	ZEB1	HT-29、SW620	抑制干性	［68］
miR-508	ZEB1、BMI1、SALL4	HCT116	抑制干性、EMT	［69］
miR-34	C-Kit	SW480、DLD-1	抑制增殖、干性、化疗耐药、迁移和侵袭	［70］

miRNAs	靶基因	细胞系	功能	参考文献
miR-106a	DUSP2	HCT116、SW620	促进5-Fu耐药	［60］
miR-27a	APAF-1	HT29、SW480	促进TRAIL耐药	［61］
miR-221	QKI-5	HCT116	促进增殖、干性	［62］
miR-17	CYP7B1	DLD1	促进干性、EMT	［63］
miR-106b	CDKN1A（P21）	SW620、SW480	促进辐射抗性	［35］
miR-196b-5p	SOCS1/3	HCT116、SW480	促进干性、化疗耐药	［32］
miR-133b	DOT1L	HT29、HCT116、SW620	抑制干性、化疗耐药	［64］
miR-146b-5p、miR5095p	WBSCR22	DLD1、RKO	抑制干性、化疗耐药	［65, 66］
miR-4711-5p	TFDP1、MDM2	DLD-1、HCT116	诱导G1期阻滞、促进凋亡	［45］
miR-124	PRRX1	SW480、LOVO	抑制干性、放疗抗性	［67］
miR-328	MMP16	SW1116、SW480	抑制干性、耐药、侵袭	［57］
miR-203	IL-8	HCT-116、HT-29	抑制干性	［43］
miR-200b	ZEB1	HT-29、SW620	抑制干性	［68］
miR-508	ZEB1、BMI1、SALL4	HCT116	抑制干性、EMT	［69］
miR-34	C-Kit	SW480、DLD-1	抑制增殖、干性、化疗耐药、迁移和侵袭	［70］

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