Research progress of ferroptosis in colorectal diseases

doi:10.3877/cma.j.issn.2095-3224.2021.01.013

Abstract

Abstract:

Ferroptosis is a newly recognized form of iron-dependent regulated cell death. The core of its occurrence is the excessive accumulation of lipid reactive oxygen species, a process affected by multiple molecular pathways. Previous studies on colorectal diseases have found that activation of the ferroptosis-related pathways is an important pathogenesis of cell death in non-neoplastic diseases, and can inhibit the occurrence and progression of colorectal cancer. The combination of targeted ferroptosis therapy and traditional therapy is expected to be a new direction in the treatment of colorectal diseases.

Key words: Colorectal neoplasms, Reactive oxygen species, Ferroptosis, Therapy

Huan Xiong, Yihao Zhu, Zhiqiao Hu, Ziming Yuan, Hanqing Hu, Qingchao Tang. Research progress of ferroptosis in colorectal diseases[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2021, 10(01): 86-89.

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