Fecal Enterococcus faecalis for prediction of recurrence in colorectal cancer

doi:10.3877/cma.j.issn.2095-3224.2021.01.012

Abstract

Abstract:

Objective

To explore the significance of the abundance of enterococcus faecalis in the prediction of recurrence in patients with colorectal cancer.

Methods

All The 103 fecal samples were collected from patients with recurrent colorectal cancer and non-recurrent colorectal cancer at the deparment of general surgery in the fourth affiliated hospital of Harbin Medical University. 16S sequencing technology was used to search for different intestinal flora. Statistical analysis was used to explore the relationship between different flora and clinical pathological indicators of patients and relapse-free survival.

Results

Enterococcus faecalis in patients with recurrent organization is higher abundance in stool samples, the patients who have higher abundance in stool samples has more pathological indicators of poor prognosis, meanwhile we also find that high abundance of dung enterococcus in patients have shorter total survival time and shorter relapse-free survival.

Conclusion

The abundance of Enterococcus faecalis in fecal samples may be a new marker to judge the prognosis of patients with colorectal cancer in the future.

Key words: Colorectal neoplasms, Enterococcus faecalis, Prognosis, Recurrence, Recurrence-free survival(RFS), Lymph node metastasis

Zhong Li. Fecal Enterococcus faecalis for prediction of recurrence in colorectal cancer[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2021, 10(01): 81-85.

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URL: https://zhjzcjbdzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-3224.2021.01.012

https://zhjzcjbdzzz.cma-cmc.com.cn/EN/Y2021/V10/I01/81

Figures/Tables 6

References 37

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组别	粪肠球菌低丰度组（51例）	粪肠球菌高丰度组（52例）	检验值	P值
年龄(岁)	60.73±4.26	59.67±5.84	1.05	0.296
性别			0.47	0.494
男	26	30
女	25	22
T分期			0.43	0.762
T2	12	7
T3	26	21
T4	13	24
N分期			10.69	＜0.01
N0	22	12
N1	20	23
N2	9	17
肿瘤分期			11.25	＜0.01
Ⅰ	8	4
Ⅱ	14	8
Ⅲ	29	40
淋巴结转移数目（个）	2.64±1.12	4.08±0.92	7.13	＜0.01
血管瘤栓			4.27	0.039
是	12	32
否	39	20
淋巴管瘤栓			4.04	0.036
是	10	34
否	41	18
神经侵犯			3.92	0.028
是	14	23
否	37	29

组别	粪肠球菌低丰度组（51例）	粪肠球菌高丰度组（52例）	检验值	P值
年龄(岁)	60.73±4.26	59.67±5.84	1.05	0.296
性别			0.47	0.494
男	26	30
女	25	22
T分期			0.43	0.762
T2	12	7
T3	26	21
T4	13	24
N分期			10.69	＜0.01
N0	22	12
N1	20	23
N2	9	17
肿瘤分期			11.25	＜0.01
Ⅰ	8	4
Ⅱ	14	8
Ⅲ	29	40
淋巴结转移数目（个）	2.64±1.12	4.08±0.92	7.13	＜0.01
血管瘤栓			4.27	0.039
是	12	32
否	39	20
淋巴管瘤栓			4.04	0.036
是	10	34
否	41	18
神经侵犯			3.92	0.028
是	14	23
否	37	29

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