The expression and clinical significance of plasma circPRMT5 in colorectal cancer patients

doi:10.3877/cma.j.issn.2095-3224.2019.04.012

Abstract

Abstract:

Objective

To investigate the clinical significance of plasma circRNA in colorectal cancer patients.

Methods

All the plasma were collected from colorectal cancer patients and healthy population, and the differently expressed circRNA were detected by Array and PCR. Then, we explored the correlation between circRNA and pathological indicators and patients′ prognosis.

Results

circPRMT5 was highly expressed in colorectal cancer patients. The expression of circPRMT5 had a correlation with the late stage, lymph node metastasis and prognosis. We also found the higher expression of circPRMT5 predicted a poor prognosis. Through univariate and multivariate analysis, we found circPRMT5 was an independent factor to predict the colorectal cancer patients prognosis.

Conclusion

circPRMT5 is a novel plasma molecular with clinical significance.

Key words: Colorectal neoplasms, circPRMT5, Prognosis, Lymph node metastasis

Hongwei Wang, Linlin Wang, Yifei Zhang, Yongsheng Yu, Yuwei Liu, Zhong Li, Xinran Liu. The expression and clinical significance of plasma circPRMT5 in colorectal cancer patients[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2019, 08(04): 390-394.

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Figures/Tables 5

References 16

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组别		circPRMT5低表达组（n=138）	circPRMT5高表达组（n=138）	检验值	P值
年龄		56.33±14.32	61.14±10.54	3.17	0.002
性别		?	?	4.44	0.035
?	男	89	105	?	?
?	女	49	33	?	?
T分期		?	?	8.40	0.036
?	T1	74	65	?	?
?	T2	25	43	?	?
?	T3	35	24	?	?
?	T4	4	6	?	?
N分期		?	?	0.37	0.911
?	N0	104	106	?	?
?	N1	2	1	?	?
?	N2	32	31	?	?
肿瘤分期		?	?	7.2	0.028
?	Ⅰ	75	64	?	?
?	Ⅱ	28	41	?	?
?	Ⅲ	35	33	?	?
淋巴结转移数目		4.74±0.86	5.12±1.25	2.94	0.004
血管瘤栓		?	?	5.44	0.020
?	是	73	92	?	?
?	否	65	46	?	?
淋巴管瘤栓		?	?	6.22	0.010
?	是	32	51	?	?
?	否	106	87	?	?
神经侵犯		?	?	5.36	0.020
?	是	49	68	?	?
?	否	89	70	?	?

组别		circPRMT5低表达组（n=138）	circPRMT5高表达组（n=138）	检验值	P值
年龄		56.33±14.32	61.14±10.54	3.17	0.002
性别		?	?	4.44	0.035
?	男	89	105	?	?
?	女	49	33	?	?
T分期		?	?	8.40	0.036
?	T1	74	65	?	?
?	T2	25	43	?	?
?	T3	35	24	?	?
?	T4	4	6	?	?
N分期		?	?	0.37	0.911
?	N0	104	106	?	?
?	N1	2	1	?	?
?	N2	32	31	?	?
肿瘤分期		?	?	7.2	0.028
?	Ⅰ	75	64	?	?
?	Ⅱ	28	41	?	?
?	Ⅲ	35	33	?	?
淋巴结转移数目		4.74±0.86	5.12±1.25	2.94	0.004
血管瘤栓		?	?	5.44	0.020
?	是	73	92	?	?
?	否	65	46	?	?
淋巴管瘤栓		?	?	6.22	0.010
?	是	32	51	?	?
?	否	106	87	?	?
神经侵犯		?	?	5.36	0.020
?	是	49	68	?	?
?	否	89	70	?	?

?		单因素分析			多因素分析
OS		HR	95%CI	P值	HR	95%CI	P值
circPRMT5表达水平		?	?	?	?	?	?
?	低表达	0.52	0.32~0.83	0.007	0.49	0.29~1.14	0.010
?	高表达	1	-	-	1	-	-
RFS		?	?	?	?	?	?
circPRMT5表达水平		?	?	?	?	?	?
?	低表达	0.59	0.39~0.88	0.01	0.66	0.46~0.95	0.026
?	高表达	1	-	-	-	-	-

?		单因素分析			多因素分析
OS		HR	95%CI	P值	HR	95%CI	P值
circPRMT5表达水平		?	?	?	?	?	?
?	低表达	0.52	0.32~0.83	0.007	0.49	0.29~1.14	0.010
?	高表达	1	-	-	1	-	-
RFS		?	?	?	?	?	?
circPRMT5表达水平		?	?	?	?	?	?
?	低表达	0.59	0.39~0.88	0.01	0.66	0.46~0.95	0.026
?	高表达	1	-	-	-	-	-

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