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Chinese Journal of Colorectal Diseases(Electronic Edition) ›› 2019, Vol. 08 ›› Issue (03): 267-271. doi: 10.3877/cma.j.issn.2095-3224.2019.03.011

Special Issue:

• Original Article • Previous Articles     Next Articles

Effect of CD151 on the expression of β-catenin and the angiogenesis in colorectal cancer

Xuegang Liu1, Yancai Liu2, Chunping Wu2, Jingguang Li2, Lingling Zhao2, Hao Zhang1, Xiaobing Peng2, Zhenya Zhang3,()   

  1. 1. Department of General Surgery, the Fourth People′s Hospital of Hengshui City, Hengshui 053000, China
    2. Department of Pathology, the Fourth People′s Hospital of Hengshui City, Hengshui 053000, China
    3. the Second Department of Surgery, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China
  • Received:2018-10-15 Online:2019-06-25 Published:2019-06-25
  • Contact: Zhenya Zhang
  • About author:
    Corresponding author: Zhang Zhenya, Email:

Abstract:

Objective

To explore the effect and mechanism of CD151 on angiogenesis in colorectal cancer (CRC).

Methods

The expression of CD151 and β-catenin were detected by Western blot and RT-qPCR in HT-29 and CD151--HT29 cells. The microvessel density of the transplanted tumor tissues was observed by immunohistochemistry CD34 labeled vascular endothelial cells.

Results

The expression of CD151 and β-catenin were lower in CD151--HT29 cells compared with HT29 cells (P<0.05). The microvessel density (MVD) count of the CD151--HT29 group was significantly lower than that of the HT-29 group (P<0.05).

Conclusion

CD151 could promote angiogenesis via up-regulate β-catenin in CRC.

Key words: Colorectal neoplasms, CD151, β-catenin, Immunohistochemistry

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