Effect of CD151 on the expression of β-catenin and the angiogenesis in colorectal cancer

doi:10.3877/cma.j.issn.2095-3224.2019.03.011

Abstract

Abstract:

Objective

To explore the effect and mechanism of CD151 on angiogenesis in colorectal cancer (CRC).

Methods

The expression of CD151 and β-catenin were detected by Western blot and RT-qPCR in HT-29 and CD151--HT29 cells. The microvessel density of the transplanted tumor tissues was observed by immunohistochemistry CD34 labeled vascular endothelial cells.

Results

The expression of CD151 and β-catenin were lower in CD151--HT29 cells compared with HT29 cells (P<0.05). The microvessel density (MVD) count of the CD151--HT29 group was significantly lower than that of the HT-29 group (P<0.05).

Conclusion

CD151 could promote angiogenesis via up-regulate β-catenin in CRC.

Key words: Colorectal neoplasms, CD151, β-catenin, Immunohistochemistry

Xuegang Liu, Yancai Liu, Chunping Wu, Jingguang Li, Lingling Zhao, Hao Zhang, Xiaobing Peng, Zhenya Zhang. Effect of CD151 on the expression of β-catenin and the angiogenesis in colorectal cancer[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2019, 08(03): 267-271.

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