The incidence and mortality rates of colorectal cancer are continually increasing worldwide. The main cause of death is liver metastasis. Rapid development of modern medical technology contribute to the update of diagnosis concept and treatment. With the ideas of personalized treatment and multidisciplinary team are put forward and rapid development of surgical skill and local treatment, the over survival time has been extended significantly. The application of colorectal liver metastases neoadjuvant therapy helps to reduce the tumor stage, improve the resection rate, and then benefit the patient. This has also been confirmed in other solid tumors. But whether neoadjuvant therapy can improve overall survival or all patients could benefit from local treatment is still controversial. The research progress on colorectal cancer liver metastasis neoadjuvant therapy is reviewed in this paper.