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Chinese Journal of Colorectal Diseases(Electronic Edition) ›› 2024, Vol. 13 ›› Issue (05): 353-361. doi: 10.3877/cma.j.issn.2095-3224.2024.05.001

• Guideline and Consensus •     Next Articles

Guidelines on prevention,diagnosis,and treatment of nausea and vomiting caused by neoadjuvant therapies for rectal cancer

Anti-cancer Association Colorectal Tumor Integrated Rehabilitation Committee, Neoadjuvant Therapy for Rectal Cancer Professional Committee of Beijing Cancer Prevention & Treatment Society Chinese   

  • Received:2024-08-12 Online:2024-10-25 Published:2024-11-14

Abstract:

Neoadjuvant radiochemotherapy is the standard treatment for locally advanced rectal cancer. In recent years,the exploration of treatment modalities such as total neoadjuvant therapy(TNT)and neoadjuvant immunotherapy has led to the continuous improvement of the efficacy of neoadjuvant therapy,but treatment-related nausea and vomiting are still common,which not only affects the quality of life,but also reduces the adherence to the treatment,especially in the case of a long course of treatment such as the total neoadjuvant therapy,which may lead to delayed or interrupted treatment and seriously affects the effectiveness of the treatment. At present,there is a lack of specialized guidelines for the prevention,diagnosis,and treatment of nausea and vomiting associated with neoadjuvant therapy for rectal cancer. For this reason,the Chinese Anti-cancer Association Colorectal Tumor Integrated Rehabilitation Committee and Beijing Cancer Prevention & Treatment Society have organized experts to consolidate the relevant research progress in recent years,follow the evidence of domestic and international evidence-based medical science,refer to the existing guidelines and experts' consensus,and combine with the clinical practice. The guideline aims to provide professional guidance and suggestions for the prevention and treatment of nausea and vomiting side effects associated with neoadjuvant therapy for rectal cancer,to improve the prognosis and quality of life of patients and therapeutic effect.

Key words: Rectal neoplasms, Neoadjuvant therapy, Nausea, Vomiting, Guidelines

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