Research progress in intestinal mucosal barrier damage and protective molecular mechanism

doi:10.3877/cma.j.issn.2095-3224.2018.03.016

Abstract

Abstract:

This paper reviews the molecular mechanism of intestinal mucosal barrier damage factors, such as endotoxin and oxygen free radicals, inflammatory mediators and cytokines such as interleukin (IL), tumor necrosis factor-α (TNF-α), nuclear transcription factor kappa B and TOLL like receptor (TLRs) and NOD receptor pathway, HMGB1, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) etc. The protective molecular mechanisms of intestinal mucosal barrier such as intestinal epithelial tight connexin, interleukin family, and other protective regulatory factors are introduced.

Key words: Intestinal mucosal barrier, Intestinal mucosal injury, Inflammation

Sheng Xu, Shunrong Huang. Research progress in intestinal mucosal barrier damage and protective molecular mechanism[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2018, 07(03): 276-280.

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References 29

[1]	Swank GM, Deitch EA. Role of the gut in multiple organ failure: bacterial translocation and permeability changes [J]. World Journal of Surgery, 1996, 20(4): 411-417.
[2]	Ammori BJ, Fitzgerald P, Hawkey P, et al. The early increase in intestinal permeability and systemic endotoxin exposure in patients with severe acute pancreatitis is not associated with systemic bacterial translocation: molecular investigation of microbial DNA in the blood [J]. Pancreas, 2003, 26(1): 18-22.
[3]	Fishman JE, Levy G, Alli V, et al. The intestinal mucus layer is a critical component of the gut barrier that is damaged during acute pancreatitis [J]. Shock, 2014, 42(3): 264-270.
[4]	Sasaki M, Joh T. Oxidative Stress and Ischemia-Reperfusion Injury in Gastrointestinal Tract and Antioxidant, Protective Agents [J]. Journal of Clinical Biochemistry & Nutrition, 2007, 40(1): 1.
[5]	Xiao YT, Yan WH, Cao Y, et al. Neutralization of IL-6 and TNF-α ameliorates intestinal permeability in DSS-induced colitis [J]. Cytokine, 2016, 83(7): 189-192.
[6]	Satoh A, Shimosegawa T, Fujita M, et al. Inhibition of nuclear factor-kappaB activation improves the survival of rats with taurocholate pancreatitis [J]. Gut, 1999, 44(2): 253-258.
[7]	Poyet JL, Alnemri ES. NF-κB Activation by Card Proteins[M]. Nuclear Factor Кb, 2003: 69-88.
[8]	Brenmoehl J, Herfarth H, Glück T, et al. Genetic variants in the NOD2/CARD15 gene are associated with early mortality in sepsis patients [J]. Intensive care medicine, 2007, 33(9): 1541-1548.
[9]	Qian M, Fang L, Cui Y. Expression of NOD2 in a rat model of acute pancreatitis [J]. Pancreas, 2010, 39(7): 1034-1040.
[10]	Sims GP, Rowe DC, Rietdijk ST, et al. HMGB1 and RAGE in Inflammation and Cancer [J]. Annual Review of Immunology, 2010, 28(28): 367.
[11]	张伟杰, 徐桂芳, 田志强, 等. 高迁移率族蛋白B1与急性胰腺炎肠黏膜屏障损伤关系的研究 [J]. 胃肠病学, 2012, 17(11): 669-672.
[12]	Hasegawa A, Iwasaka H, Hagiwara S, et al. Relationship Between HMGB1 and Tissue Protective Effects of HSP72 in a LPS-Induced Systemic Inflammation Model [J]. Journal of Surgical Research, 2011, 169(1): 85.
[13]	Yu JH, Kim KH, Kim H. Role of NADPH oxidase and calcium in cerulein-induced apoptosis: involvement of apoptosis-inducing factor [J]. Annals of the New York Academy of Sciences, 2006, 1090(1): 292.
[14]	Yu JH, Lim JW, Kim H, et al. NADPH oxidase mediates interleukin-6 expression in cerulein-stimulated pancreatic acinar cells [J]. International Journal of Biochemistry & Cell Biology, 2007, 39(11): 2063.
[15]	Gukovskaya AS, Vaquero E, Zaninovic V, et al. Neutrophils and NADPH oxidase mediate intrapancreatic trypsin activation in murine experimental acute pancreatitis [J]. Gastroenterology, 2002, 122(4): 974-984.
[16]	张琛琛. NOX1和NOX4在小鼠脑缺血再灌注损伤中的表达及功能[D]. 2012, 华中科技大学.
[17]	郭毅斌, 郑江, 吕根法, 等. MP-1对脓毒症小鼠的保护作用及其机制 [J]. 中华创伤杂志, 2004, 20(11): 678-681.
[18]	Lambeth JD. NOX enzymes and the biology of reactive oxygen [J]. Nature Reviews Immunology, 2004, 4(3): 181.
[19]	Conway EM. Thrombomodulin and its role in inflammation [J]. Seminars in Immunopathology, 2012, 34(1): 107.
[20]	丁志辉, 张红艳. 热休克蛋白70的胃肠黏膜分子伴侣保护作用及免疫调节功能 [J]. 南昌大学学报(医学版), 2009, 49(1): 136-138.
[21]	邓鸿敖, 张红艳, 熊林朋, 等. 细胞外热休克蛋白70对严重烫伤大鼠肠道免疫功能的影响 [J]. 中华烧伤杂志, 2016, 32(5): 272-276.
[22]	Tsuruma T, Yagihashi A, Matsuno T, et al. The heat-shock protein 70 family reduces ischemia/reperfusion injury in small intestine [J]. Transplantation Proceedings, 1996, 28(5): 2629-2630.
[23]	Afrazi A, Korff S, Loughran P, et al. Intestinal Heat Shock Protein 70 (HSP70) Over Expression Attenuates Local and Remote Inflammation and Organ Injury Following Hemorrhagic Shock and Trauma [J]. Journal of Surgical Research, 2012, 172(2): 325-325.
[24]	蔡慧云, 魏晓军, 齐心, 等. 白细胞介素11调控大鼠NEC肠道增殖与凋亡的分子机制研究 [J]. 中华普外科手术学杂志电子版, 2016, 10(4): 340-343.
[25]	杨学超, 东传凌. 白细胞介素22在肠道损伤修复中的研究进展 [J]. 医学综述, 2016, 22(2): 242-244.
[26]	张新艳. IL-22及其受体IL-22RA1在肠上皮损伤修复中的功能研究 [D]. 2015, 华东师范大学.
[27]	柏超, 陈霞, 李昌平. HMGB1在重症急性胰腺炎肠黏膜屏障损伤中作用的研究进展 [J]. 山东医药, 2016, 56(34): 103-105.
[28]	Ahmed MA, Jackson D, Seth R, et al. CD24 is upregulated in inflammatory bowel disease and stimulates cell motility and colony formation [J]. Inflammatory Bowel Diseases, 2010, 16(5): 795.
[29]	吴国豪. 肠屏障功能障碍及防治对策 [J]. 肠外与肠内营养, 2004, 11(5): 313-316.

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