Abstract:
Objective To investigate the laparoscopic colorectal cancer radical resection combined with fast track surgery effect on immune function and inflammatory responses.
Methods Clinical retrospective data were analyzed for 150 cases of colorectal cancer patients, of who laparoscopy combined with rapid rehabilitation surgical treatment (experimental group) and raditional open surgery (control group)were underwent in 60 cases and 90 cases, respectively. Comparative analysis of C-reactive protein, CD4+T cells (%), CD8+T cells (%), CD4+/CD8+ level between two groups of patients before and after surgery, in the day of 1,4,7.
Results All patients were successfully completed surgery, postoperative recovery was good. Two groups of patients with postoperative CRP were higher than that before operation. Compared with the experimental group, the control group increased more (P<0.01); 1 day after operation, CD4+T cells (%), CD8+T cells (%), CD4+/CD8+ level were decreased, control group decreased obviously in the experimental group and the control group (P<0.01), after day 4,7 the level was still low.
Conclusion Compared with conventional open surgery, laparoscopic surgery combined with rapid rehabilitation surgery has less influence on the immune function of patients, and the patients recover more quickly.
Key words:
Colorectal neoplasms,
Laparoscopy,
Fast track surgery,
Immune function
Li Lu, Min Xie, Zhiguo Xiong. Application of fast track surgery in the perioperative period of colorectal cancer[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2016, 05(04): 333-337.