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Chinese Journal of Colorectal Diseases(Electronic Edition) ›› 2015, Vol. 04 ›› Issue (01): 58-61. doi: 10.3877/cma.j.issn.2095-3224.2015.01.13

Special Issue:

• Original Article • Previous Articles     Next Articles

Expression and the significance of caspase recruitment domain family member10 in colorectal cancer

Ting-ting ZHAO1, Peng XING1, Ji-guang LI1,()   

  1. 1. Tumor Research Institute of China Medical University, Shenyang 110013, China
  • Received:2015-01-20 Online:2015-02-25 Published:2015-02-25
  • Contact: Ji-guang LI
  • About author:
    Corresponding author: LI Ji-guang, Email: .

Abstract:

Objective

To investigate the expression and the significance of CARD10(caspase recruitment domain family member 10)in colorectal cancer.

Methods

The expression of CARD10 was detected by immunohistochemistry.The statistic analysis was performed by SPSS 19.0.

Results

Overexpression of CARD10 was found in 46(31.29%)patients and 10(6.80%)patients in colorectal cancer tissues and tumor-adjacent mucosae, respectively.CARD10 was overexpressed in colorectal cancer(P<0.01). Overexpression of CARD10 in colorectal cancer correlated with TNM stage(P<0.01), tumor depth(P<0.05), nodal metastasis(P<0.01), distant metastasis(P<0.05), and Ki-67 status(P<0.01).

Conclusion

This study demonstrated that CARD10 may play a role as tumor-promoting factor in colorectal cancer.

Key words: Colorectal neoplasms, Immunohistochemistry, CARD10

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