Retrospective studies of pseudomembranous colitis after gastrointestinal cancer surgery

doi:10.3877/cma.j.issn.2095-3224.2015.01.07

Abstract

Abstract:

Objective

To study the clinical features of pseudomembranous colitis(PMC)in our surgical ward.

Methods

The clinical data of 107 men and 129 women who developed PMC from January 2010 to December 2012 were analyzed.

Results

The underlying diseases were as follows: gastric cancer(n=61), colon cancer(n=98)and rectal cancer(n=77). The mean age of patients was 64.5 years(range 35-78). In 201 cases PMC developed within 6 days of operation.All patients were treated with metronidazole and bacillus bifidus, 61 plus vancomycin through a nasogastric tube or by oral.233 patients survived and 3 died.

Conclusions

Patients who are given broad-spectrum antibiotics and whose gastric secretion is reduced are at high risk of PMC.The reasonable application of antibiotics and paying attention to the early application of enteral nutrition can reduce the occurrence of PMC.In the surgical ward, early diagnosis, treatment and isolation are essential for patients with PMC.

Key words: Enterocolitis, pseudomembranous, Gastrointestinal neoplasms, Clostridium, Antibiotics, antifungal

Jun-yan ZHANG, Zhi-feng MIAO, Jin-yu Huang, Hui-mian XU. Retrospective studies of pseudomembranous colitis after gastrointestinal cancer surgery[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2015, 04(01): 32-35.

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Figures/Tables 3

References 14

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组别	患者数量(例)
胃癌	?
胃远端大部切除术	38
胃近端大部切除术	5
全胃切除术	16
单纯胃肠吻合术	2
结肠癌	?
左半结肠切除术	35
右半结肠切除术	63
直肠癌	?
直肠低位前切除术	42
Miles手术	25
Hartmann手术	10

组别	患者数量(例)
胃癌	?
胃远端大部切除术	38
胃近端大部切除术	5
全胃切除术	16
单纯胃肠吻合术	2
结肠癌	?
左半结肠切除术	35
右半结肠切除术	63
直肠癌	?
直肠低位前切除术	42
Miles手术	25
Hartmann手术	10

年龄(岁)	患者数量(例)
35-49	24
50-59	64
60-69	111
70-78	37

年龄(岁)	患者数量(例)
35-49	24
50-59	64
60-69	111
70-78	37

抗生素	患者数量	剂量
头孢美唑钠	136	2.0g日2次静点(1-7d)
头孢哌酮钠/舒巴坦钠	55	2.0g日2次静点(1-7d)
哌拉西林钠他唑巴坦钠	25	4.5g每8小时静点(1-6d)
左氧氟沙星	17	0.4g日1次静点(1-5d)
美罗培南	3	1.0g每8小时静点(3-5d)

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