Colorectal cancer(colorectal cancer, CRC)is one of the world's commonest gastrointestinal cancer, about 50% of patients develop liver metastases eventually.For patients with liver metastases, if liver metastases are not treated, the median survival time would be 6.9 months, while the 5-year survival rate would be 0.If the liver metastases are treated with radical surgery, the median survival time would be 35 months, while 5-year survival rate would be 30-50%.Surgical resection is still the preferred treatment for patients with liver metastases.For patients with liver metastases, if there are no intestinal obstruction, perforation, bleeding or other symptoms, the author tends to perform simultaneous resection of the primary tumor and metastases, surgery combined with ultrasound, microwave, RFA, or other new technologies to improve the resection rate and reduce the relapse.But only a small number of patients(10%-15%)can be treated surgically.For unresectable liver metastases, we need the multi-disciplinary group of experts to make detailed, individualized and comprehensive treatment, which includes neoadjuvant chemotherapy, combining targeted drug therapy, portal vein embolization applications, topical treatment, radiotherapy and so on, to make some unresectable lesions resectable.As cancer is a systemic disease, It is difficult to be cured with one single treatment we need the cooperation of multidisciplinary to to find the best treatment for a certain period of the disease.Meanwhile Follow-up, timely detection of recurrence and metastasis, and further treatment plans for long-term survival and improved quality of life of patients can not be ignored.