The study of USP22 activation in colorectal cancer

doi:10.3877/cma.j.issn.2095-3224.2014.02.05

Abstract

Abstract:

Objective

To investigate the expression of USP22 in colorectal carcinoma.

Methods

192 cases of colorectal carcinoma were examined by immunohistochemical staining.

Results

USP22 expression significantly increased from normal mucosa and adenoma to primary carcinoma(P<0.0001). And increased from primary carcinoma to liver metastasis(P=0.021)as well.Expression of USP22 was highly correlated with gender, tumor size, pT, pN, and Ki-67 expression(P<0.05).

Conclusion

USP22 protein could be useful in evaluating the malignancy of colorectal cancer.

Key words: Colorectal neoplasms, Metastasis, USP22

Zheng JIANG, Yan-long LIU, Xi-shan WANG. The study of USP22 activation in colorectal cancer[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2014, 03(02): 95-98.

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Figures/Tables 3

References 7

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变量		数量	USP22阴性	USP22阳性	P值
年龄(岁)		?	?	?	?
?	<60	103	47	56	0.952
?	≥60	89	41	48	0.952
性别		?	?	?	?
?	男	112	44	68	0.031
?	女	80	44	36	?
肿瘤部位		?	?	?	?
?	结肠	76	31	45	0.301
?	直肠	116	57	59	?
肿瘤大小(cm)		?	?	?	?
?	<5	76	45	31	0.003
?	≥5	116	43	73	?
浸润深度		?	?	?	?
?	T1-3	104	64	40	<0.0001
?	T4	88	24	64	?
淋巴结受累程度		?	?	?	?
?	N0	112	61	51	0.005
?	N1-2	80	27	53	?
Ki-67表达		?	?	?	?
?	阴性	69	52	17	<0.0001
?	阳性	123	36	87	?

变量		数量	USP22阴性	USP22阳性	P值
年龄(岁)		?	?	?	?
?	<60	103	47	56	0.952
?	≥60	89	41	48	0.952
性别		?	?	?	?
?	男	112	44	68	0.031
?	女	80	44	36	?
肿瘤部位		?	?	?	?
?	结肠	76	31	45	0.301
?	直肠	116	57	59	?
肿瘤大小(cm)		?	?	?	?
?	<5	76	45	31	0.003
?	≥5	116	43	73	?
浸润深度		?	?	?	?
?	T1-3	104	64	40	<0.0001
?	T4	88	24	64	?
淋巴结受累程度		?	?	?	?
?	N0	112	61	51	0.005
?	N1-2	80	27	53	?
Ki-67表达		?	?	?	?
?	阴性	69	52	17	<0.0001
?	阳性	123	36	87	?

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