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中华结直肠疾病电子杂志 ›› 2021, Vol. 10 ›› Issue (01) : 86 -89. doi: 10.3877/cma.j.issn.2095-3224.2021.01.013

所属专题: 文献

综述

铁死亡在结直肠疾病中的研究进展
熊寰1, 朱亿豪1, 胡志乔1, 袁子茗1, 胡汉卿1, 汤庆超1,()   
  1. 1. 150081 哈尔滨医科大学附属第二医院结直肠肿瘤外科
  • 收稿日期:2020-05-20 出版日期:2021-02-25
  • 通信作者: 汤庆超
  • 基金资助:
    吴阶平医学基金会(No.320.2710.1849)

Research progress of ferroptosis in colorectal diseases

Huan Xiong1, Yihao Zhu1, Zhiqiao Hu1, Ziming Yuan1, Hanqing Hu1, Qingchao Tang1,()   

  1. 1. Department of Colorectal Cancer Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China
  • Received:2020-05-20 Published:2021-02-25
  • Corresponding author: Qingchao Tang
引用本文:

熊寰, 朱亿豪, 胡志乔, 袁子茗, 胡汉卿, 汤庆超. 铁死亡在结直肠疾病中的研究进展[J/OL]. 中华结直肠疾病电子杂志, 2021, 10(01): 86-89.

Huan Xiong, Yihao Zhu, Zhiqiao Hu, Ziming Yuan, Hanqing Hu, Qingchao Tang. Research progress of ferroptosis in colorectal diseases[J/OL]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2021, 10(01): 86-89.

铁死亡是一种新发现的铁依赖的调节性细胞死亡形式,其发生的核心在于脂质活性氧(L-ROS)的过量累积,而这一过程受多条分子通路的影响。既往结直肠疾病的相关研究发现,铁死亡通路被激活是非肿瘤性疾病中细胞死亡的重要机制,同时也能抑制结直肠肿瘤的发生与发展。靶向铁死亡治疗方式与传统治疗方式联合应用有望成为结直肠疾病治疗新方向。

Ferroptosis is a newly recognized form of iron-dependent regulated cell death. The core of its occurrence is the excessive accumulation of lipid reactive oxygen species, a process affected by multiple molecular pathways. Previous studies on colorectal diseases have found that activation of the ferroptosis-related pathways is an important pathogenesis of cell death in non-neoplastic diseases, and can inhibit the occurrence and progression of colorectal cancer. The combination of targeted ferroptosis therapy and traditional therapy is expected to be a new direction in the treatment of colorectal diseases.

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