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中华结直肠疾病电子杂志 ›› 2020, Vol. 09 ›› Issue (05) : 447 -452. doi: 10.3877/cma.j.issn.2095-3224.2020.05.003

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肿瘤间质成分在结直肠癌中的研究现状及进展
李腾飞1, 黄陈2,()   
  1. 1. 201600 上海交通大学附属第一人民医院胃肠外科;233000 蚌埠医学院第一附属医院胃肠外科
    2. 201600 上海交通大学附属第一人民医院胃肠外科
  • 收稿日期:2020-05-13 出版日期:2020-10-25
  • 通信作者: 黄陈
  • 基金资助:
    国家自然科学基金面上项目(No.817725276); 上海交通大学医院高峰高原计划(No.20161425); 上海交通大学医工交叉项目(No.YG2017MS28); 上海松江科技攻关项目(No.18SJKJGG23,No.19SJKJGG22)

Tumor stroma ingredient in colorectal cancer: Current status and perspectives

Tengfei Li1, Chen Huang2,()   

  1. 1. Department of Gastrointestinal Surgery, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 201600, China; Department of Gastrointestinal Surgery, the First Affiliated Hospital, Bengbu Medical College, Bengbu 233000, China
    2. Department of Gastrointestinal Surgery, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 201600, China
  • Received:2020-05-13 Published:2020-10-25
  • Corresponding author: Chen Huang
  • About author:
    Corresponding author: Huang Chen, Email:
引用本文:

李腾飞, 黄陈. 肿瘤间质成分在结直肠癌中的研究现状及进展[J]. 中华结直肠疾病电子杂志, 2020, 09(05): 447-452.

Tengfei Li, Chen Huang. Tumor stroma ingredient in colorectal cancer: Current status and perspectives[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2020, 09(05): 447-452.

结直肠癌(CRC)是全球最常见的消化道恶性肿瘤之一,其发病率逐年增高。研究表明,肿瘤间质(tumor stroma)在肿瘤发生发展的过程中具有重要作用。肿瘤间质,通过与肿瘤实质的相互影响,促进了CRC的发生、发展和转移。因此,探究肿瘤间质成分在CRC进展中的具体作用、分子机制及其临床应用至关重要。本文就目前国内外肿瘤间质成分在CRC中的研究进展进行综述。

Colorectal cancer (CRC) is one of the most common gastrointestinal malignant tumors worldwide, and its incidence is increasing year by year. Studies have shown that tumor stroma plays an active role in the occurrence and development of tumors. Tumor stroma, through the interaction with tumor essence ingredient, it affects the progression of CRC and the ability of tumor metastasis it promotes the occurrence, development and metastasis of CRC. Therefore, it is very important to explore the specific role, molecular mechanism and mechanism of tumor stroma components in the progression of CRC clinical application is essential. This article reviews the current research progress of tumor stroma in CRC at home and abroad.

图1 肿瘤微环境中的肿瘤细胞和肿瘤间质成分
表1 TILs和TAMs亚型与结直肠癌预后的相关性
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