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中华结直肠疾病电子杂志 ›› 2019, Vol. 08 ›› Issue (03) : 217 -220. doi: 10.3877/cma.j.issn.2095-3224.2019.03.001

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胃肠间质瘤个体化治疗策略的探讨
王健1, 沈朝勇1, 张波1,()   
  1. 1. 610041 成都,四川大学华西医院胃肠外科
  • 收稿日期:2018-10-15 出版日期:2019-06-25
  • 通信作者: 张波
  • 基金资助:
    国家自然科学基金面上项目(No.81572931)

Individualized treatment strategy for gastrointestinal stromal tumor

Jian Wang1, Chaoyong Shen1, Bo Zhang1,()   

  1. 1. Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China
  • Received:2018-10-15 Published:2019-06-25
  • Corresponding author: Bo Zhang
  • About author:
    Corresponding author: Zhang Bo, Email:
引用本文:

王健, 沈朝勇, 张波. 胃肠间质瘤个体化治疗策略的探讨[J]. 中华结直肠疾病电子杂志, 2019, 08(03): 217-220.

Jian Wang, Chaoyong Shen, Bo Zhang. Individualized treatment strategy for gastrointestinal stromal tumor[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2019, 08(03): 217-220.

胃肠间质瘤(GIST)是最常见的胃肠道间叶源性肿瘤,多见于胃和小肠,GIST多具有恶性潜能,生物学行为可以从良性到高度恶性不等。GIST的预后与肿瘤的发病部位、瘤体大小、核分裂数以及肿瘤是否破裂密切相关,伊马替尼辅助治疗明显延长了GIST患者的生存时间。近年对于GIST患者实施个体化治疗的理念也得到了越来越多的重视,本文就GIST个体化治疗的策略研究进行阐述。

Gastrointestinal stromal tumor (GIST) are the most common mesenchymal tumors of the gastrointestinal tract, and are commonly located in the stomach and small intestine. All GIST have malignant potential, ranging from small lesions with a benign behavior to highly malignant sarcomas. The prognosis of gastrointestinal stromal tumor is closely related to the tumor location、tumor size、mitotic count and rupture of the tumors. Adjuvant therapy with imatinib has significantly prolonged the survival time of GIST patients. Recently, more and more attention has been paid to the concept of individualized treatment for gastrointestinal stromal tumor. And this article reviews the strategy of individualized treatment for gastrointestinal stromal tumor.

[1]
Miettinen M, Sobin LH, Lasota J. Gastrointestinal stromal tumors of the stomach: a clinicopathologic immunohistochemical, and molecular genetic study of 1 765 cases with long-term follow-up [J]. Am J Surg Pathol, 2005, 29(1): 52-68.
[2]
Joensuu H. Risk stratification of patients diagnosed with gastrointestinal stromal tumor [J]. Hum Pathol, 2008, 39(10): 1411-1419.
[3]
Edge SB, Compton CC. The American Joint Committee on Cancer: the 7th Edition of the AJCC Cancer Staging Manual and the Future of TNM [J]. Annals of Surgical Oncology, 2010, 17(6): 1471-1474.
[4]
Joensuu H, Hoenberger P, Corless CL. Gastrointestinal stromal tumour [J]. Lancet, 2013, 382(9896): 973-983.
[5]
Joensuu H, Vehtari A, Riihimäki J, et al. Risk of recurrence of gastrointestinal stromal tumour after surgery: an analysis of pooled population-based cohorts [J]. Lancet Oncol, 2012, 13(3): 265-274.
[6]
Raut CP, Espat NJ, Maki RG, et al. Efficacy and Tolerability of 5-Year Adjuvant Imatinib Treatment for Patients With Resected Intermediate-or High-Risk Primary Gastrointestinal Stromal Tumor: The PERSIST-5 Clinical Trial [J]. JAMA Oncol, 2018, 4(12): e184060.
[7]
Maki RG, Blay JY, Demetri GD, et al. Key Issues in the Clinical Management of Gastrointestinal Stromal Tumors: An Expert Discussion [J]. Oncologist, 2015, 20(7): 823-830.
[8]
Joensuu H, Wardelmann E, Sihto H, et al. Effect of KIT and PDGFRA Mutations on Survival in Patients With Gastrointestinal Stromal Tumors Treated With Adjuvant Imatinib An Exploratory Analysis of a Randomized Clinical Trial [J]. JAMA Oncol, 2017, 3(5): 602-609.
[9]
Lin J, Huang C, Zheng C, et al. Laparoscopic versus open gastric resection for larger than 5 cm primary gastric gastrointestinal stromal tumors (GIST): a size-matched comparison [J]. Surg Endosc, 2014, 28(9): 2577-2583.
[10]
Yoshihide Otani, Toshiharu Furukawa, Masashi Yoshida, et al. Operative indications for relatively small (2-5 cm) gastrointestinal stromal tumor of the stomach based on analysis of 60 operated cases [J]. Surgery, 2006, 139(4): 484-492.
[11]
Khoo CY, Goh BKP, Eng AKH, et al. Laparoscopic wedge resection for suspected large(≥5 cm) gastric gastrointestinal stromal tumors [J]. Surgery Endoscopy And Other Interventional Techniques, 2017, 31(5): 2271-2279.
[12]
Yin X, Yin Y, Chen H, et al. Comparison analysis of three different types of minimally invasive procedures for gastrointestinal stromal tumors≤5 cm [J]. Journal of Laparoendoscopic & Advanced Surgical Techniques, 2018, 28(1): 58-64.
[13]
Shen C, Chen H, Yin Y, et al. Endoscopic Versus Open Resection for Small Gastric Gastrointestinal Stromal Tumors [J]. Medicine, 2015, 94(1): e376.
[14]
Chen T, Zhou PH, Chu Y, et al. Long-term Outcomes of Submucosal Tunneling Endoscopic Resection for Upper Gastrointestinal Submucosal Tumors [J]. Annals of Surgery, 2017, 265(2): 363-369.
[15]
Cai Z, Yin Y, Shen C, et al. Role of surgical resection for patients with recurrent or metastatic gastrointestinal stromal tumors: a systematic review and meta-analysis [J]. International Journal of Surgery, 2018, (56): 108-114.
[16]
Li J, Ye Y, Wang J, et al. Chinese consensus guidelines for diagnosis and management of gastrointestinal stromal tumor [J]. Chin J Cancer Res, 2017, 29(4): 281-293.
[17]
Shen C, Chen H, Yin Y, et al. Preoperative imatinib for patients with primaryunresectable or metastatic/recurrent gastrointestinal stromal tumor [J]. Clinics, 2014, 69(11): 758-762.
[18]
Tang S, Yin Y, Shen C, et al. Preoperative imatinib mesylate (IM) for huge gastrointestinal stromal tumors (GIST) [J]. World J Surg Oncol, 2017, 15(1): 79.
[19]
Yin Y, Xiang J, Tang S, et al. A lower dosage of imatinib in patients with gastrointestinal stromal tumors with toxicity of the treatment [J]. Medicine, 2016, 95(49): e5488.
[20]
Dong-Hoe K, Min-Hee R, Kyoung-Mee K, et al. Asian Consensus Guidelines for the Diagnosis and Management of Gastrointestinal Stromal Tumor [J]. Cancer Res Treat, 2016, 48(4): 1155-1166.
[21]
Mehren MV, Randall RL, Benjamin RS, et al. Soft Tissue Sarcoma, Version 2.2016, NCCN clinical practice guidelines in oncology [J]. J Natl Compr Canc Netw, 2016, 14(6): 758-786.
[22]
Shen C, Chen H, Yin Y, et al. Endoscopic versus open resection for small gastric gastrointestinal stromal tumors: safety and outcomes [J]. Medicine, 2015, 94(1): e376.
[23]
Wagner AJ, Kindler H, Gelderblom H, et al. A phase II study of a human anti-PDGFRa monoclonal antibody (olaratumab, IMC-3G3) in previously treated patients with metastatic gastrointestinal stromal tumors [J]. Annals of Oncology, 2017, 28(3): 541-546.
[24]
Joensuu H, Eriksson M, Hall KS, et al. Risk factors for gastrointestinal stromal tumor recurrence in patients treated with adjuvant imatinib [J]. Cancer, 2014, 120(15): 2325-2333.
[25]
Dematteo RP, Ballman KV, Antonescu CR, et al. adjuvant imatinib mesylate after resection of localized, primary gastrointestinal stromal tumour: a randomized, double-blind, placebo-controlled trial [J]. Lancet, 2009, 373(9669): 1097-1104.
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