2018年4月~2022年6月中国医学科学院肿瘤医院结直肠外科收治4例小肠间质瘤（SIST）患者，均在全麻下行腹部无辅助切口经自然腔道取出标本的完全腹腔镜SIST切除术，回顾性分析该4名患者的临床、病理资料。4例患者均顺利完成手术。术后病理均证实为SIST。中位肿瘤直径3.85 cm（1.2 cm~5 cm），中位手术时间90 min（60~100 min），中位术中出血10 mL（5~20 mL），中位术后排气时间21 h（12~48 h），中位术后住院时间5 d（4~7 d）。所有患者术后均无并发症发生。在经选择的SIST患者中，行腹部无辅助切口经自然腔道取出标本的完全腹腔镜SIST切除术安全可行，具有良好的近期疗效。

From April 2018 to June 2022, four patients with small intestinal stromal tumors (SIST) underwent total laparoscopic resection of small intestinal stromal tumors by natural orifice specimen extraction without abdominal incision under general anesthesia. All operations were completed successfully. Postoperative pathology confirmed small intestinal stromal tumor. Median tumor diameter was 3.85 cm (1.2 cm~5 cm). Median operative time was 90 min (60~100 min). Median intraoperative bleeding was 10 mL (5~20 mL). Median postoperative exhaust time was 21 h (12~48 h). Mean postoperative hospital stay 5 d (4~7 d). No complications occurred. In selected patients with small intestinal stromal tumors, totally laparoscopic resection of small intestinal stromal tumors with natural orifice specimen extraction is safe and feasible, and has good short-term outcomes.