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中华结直肠疾病电子杂志 ›› 2017, Vol. 06 ›› Issue (03) : 234 -237. doi: 10.3877/cma.j.issn.2095-3224.2017.03.013

所属专题: 文献

综述

沙利度胺治疗炎症性肠病的有效性及安全性分析
牟丹1, 李月月1, 李延青1,()   
  1. 1. 250012 山东大学齐鲁医院消化内科
  • 收稿日期:2016-10-19 出版日期:2017-06-25
  • 通信作者: 李延青
  • 基金资助:
    国家自然科学基金项目(No.81330012)

The analysis of efficacy and safety of thalidomide in inflammatory bowel disease

Dan Mu1, Yueyue Li1, Yanqing Li1,()   

  1. 1. Department of Gastroenterology, Laboratory of Translational Gastroenterology, Shandong University, Qilu Hospital, Jinan 250012, China
  • Received:2016-10-19 Published:2017-06-25
  • Corresponding author: Yanqing Li
  • About author:
    Corresponding author: Li Yanqing, Email:
引用本文:

牟丹, 李月月, 李延青. 沙利度胺治疗炎症性肠病的有效性及安全性分析[J/OL]. 中华结直肠疾病电子杂志, 2017, 06(03): 234-237.

Dan Mu, Yueyue Li, Yanqing Li. The analysis of efficacy and safety of thalidomide in inflammatory bowel disease[J/OL]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2017, 06(03): 234-237.

目前,沙利度胺,作为一种兼具抗炎、免疫调节和免疫抑制的廉价药物,在炎症性肠病中的应用得到了广泛关注。本文阐述了沙利度胺治疗炎症性肠病的有效性和安全性,以及其可能的作用机制。随着研究的深入,沙利度胺或可用于经糖皮质激素、免疫抑制剂或生物制剂治疗无效时的挽救治疗。

Thalidomide has received widespread attention as a cheap drug which has properties of anti-inflammatory, immunosuppression and immunomodulatory. This article elaborates the efficacy and safety of thalidomide in inflammatory bowel disease, and finds it possible mechanism. With the deepening of the research, thalidomide can be used as a salvage therapy when inflammatory bowel disease cannot induce and maintain remissions by glucocorticoid, immunosuppressive agents, biologic agents and so on.

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