切换至 "中华医学电子期刊资源库"

中华结直肠疾病电子杂志 ›› 2017, Vol. 06 ›› Issue (03) : 230 -233. doi: 10.3877/cma.j.issn.2095-3224.2017.03.012

所属专题: 文献

综述

miRNA在炎症性肠病中的研究进展
王力田1, 杨立胜1, 刘刚1,()   
  1. 1. 300052 天津医科大学总医院普通外科
  • 收稿日期:2016-11-19 出版日期:2017-06-25
  • 通信作者: 刘刚
  • 基金资助:
    黎介寿院士肠道屏障研究专项基金(No.LJS_201008)

Progress in study of microRNA in inflammatory bowel disease

Litian Wang1, Lisheng Yang1, Gang Liu1,()   

  1. 1. Department of General Surgery, The Tianjin Medical University General Hospital, Tianjin 300052, China
  • Received:2016-11-19 Published:2017-06-25
  • Corresponding author: Gang Liu
  • About author:
    Corresponding author: Liu Gang, Email:
引用本文:

王力田, 杨立胜, 刘刚. miRNA在炎症性肠病中的研究进展[J]. 中华结直肠疾病电子杂志, 2017, 06(03): 230-233.

Litian Wang, Lisheng Yang, Gang Liu. Progress in study of microRNA in inflammatory bowel disease[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2017, 06(03): 230-233.

炎症性肠病(IBD)为一类反复发作的肠道慢性非特异性炎性疾病,主要包括溃疡性结肠炎(UC)和克罗恩病(CD)。其病因及发病机制目前尚不明确,可能与多种因素有关。近年研究发现microRNA(miRNA)在IBD患者中表达异常,可能参与IBD的发生、发展。本文就IBD患者特异性miRNA表达异常的研究进展作一综述,旨在探讨miRNA在IBD发病机制、诊断和预后判断中的价值,为其临床应用提供依据。

Inflammatory bowel disease (IBD) is a chronic non-specific intestinal inflammatory disease, mainly including ulcerative colitis (UC) and crohn′s disease (CD). The etiology of IBD has not yet been clarified, and it may be relevant to many factors. Recent studies have shown that expressions of microRNA (miRNA) were frequently altered in patients with IBD, and were involved in the development of IBD. This article reviewed the aberrant miRNA expressions in patients with IBD in order to discuss the value of miRNA in the pathogenesis, diagnosis and prognosis of IBD, and to further provide the evidence for its clinical application.

[1]
Abraham C, Medzhitov R. Interactions between the host innate immune system and microbes in inflammatory bowel disease [J]. Gastroenterology, 2011, 140(6):1729-1737.
[2]
Kaser A, Zeissig S, Blumberg R. Inflammatory bowel disease [J]. Annu Rev Immunol, 2010, 28(1):573-621.
[3]
Guarnieri DJ, Dileone RJ.MicmRNAs:a new class of gene regulators [J]. Ann Med, 2008, 40(3):197-208.
[4]
Pekow JR, Kwon JH. MicroRNAs in inflammatory bowel disease [J]. Inflamm Bowel Dis, 2012, 18(1):187-193.
[5]
Polytarchou C, Oikonomopoulos A, Mahurkar S, et al. Assessment of Circulating MicroRNAs for the Diagnosis and Disease Activity Evaluation in Patients with Ulcerative Colitis by Using the Nanostring Technology [J]. Inflamm Bowel Dis, 2015, 21(11):2533-2539.
[6]
Felwick R., Dingley G., Sanchez-Elsner T., et al. MicroRNA23a is overexpressed in the colonic epithelium in Crohn′s disease [J]. Journal of Crohn′s and Colitis , 2016, 150(4):S375-S375.
[7]
Yu Q, Zhang S, Chao K, et al. E3 Ubiquitin ligase RNF183 Is a Novel Regulator in Inflammatory Bowel Disease [J]. J Crohns Colitis, 2016, 10(6):713-725.
[8]
Wu W, He C, Liu C, et al. miR-10a inhibits dendritic cell activation and Th1/Th17 cell immune responses in IBD [J]. Gut, 2015, 64(11):1755-1764.
[9]
Takagi T, Naito Y, Mizushima K, et al. Increased expression of microRNA in the inflamed colonic mucosa of patients with active ulcerative colitis [J]. J Gastroenterol Hepatol, 2010, 25(1):S129-S133.
[10]
Heinsbroek SE, Squadrito ML, Schilderink R, et al. miR-511-3p, embedded in the macrophage mannose receptor gene, contributes to intestinal inflammation [J]. Mucosal Immunol, 2016, 9(4):960-973.
[11]
Zhang L, Shen J, Cheng J, et al. MicroRNA-21 regulates intestinal epithelial tight junction permeability [J]. Cell Biochem Funct, 2015, 33(4):235-240.
[12]
Yang Y, Ma Y, Shi C, et al. Overexpression of miR-21 in patients with ulcerative colitis impairs intestinal epithelial barrier function through targeting the Rho GTPase RhoB [J]. Biochem Biophys Res Commun, 2013, 434(4):746-752.
[13]
Ye D, Guo S, Al-Sadi R, et al. MicroRNA regulation of intestinal epithelial tight junction permeability [J]. Gastroenterology, 2011, 141(4):1323-1333.
[14]
Chen Y, Wang C, Liu Y, et al. miR-122 targets NOD2 to decrease intestinal epithelial cell injury in Crohn′s disease [J]. Biochem Biophys Res Commun, 2013, 438(1):133-139.
[15]
Schaefer JS, Attumi T, Opekun AR, et al. MicroRNA signatures differentiate Crohn′s disease from ulcerative colitis [J]. BMC Immunol, 2015, 16(1):5.
[16]
Krissansen GW, Yang Y, Mcqueen FM, et al. Overexpression of miR-595 and miR-1246 in the sera of patients with active forms of inflammatory bowel disease [J]. Inflamm Bowel Dis, 2015, 21(3):520-530.
[17]
Yu N, Zhang YP, Wang FY. Differential expression of miR-155 as a novel fecal-based diagnostic marker for inflammatory bowel disease [J]. J Dig Dis, 2014, 15, SUPPL. (1):156.
[18]
Yi F, Zhou R, Xun J, et al. The utility of fecal microRNAs and S100A12 in the diagnosis of inflammatory bowel disease [J]. J Gastroenterol Hepatol, 2013, 28 SUPPL. (3):146.
[19]
Iborra M, Bernuzzi F, Correale C, et al. Identification of serum and tissue micro-RNA expression profiles in different stages of inflammatory bowel disease [J]. Clin Exp Immunol, 2013, 173(2):250-258.
[20]
Wang H, Zhang S, Yu Q, et al. Circulating MicroRNA223 is a New Biomarker for Inflammatory Bowel Disease [J]. Medicine(Baltimore), 2016, 95(5):e2703.
[21]
Link A, Schoenauen K, Le N, et al. Differential expression of micrornas in sera and feces of patients with inflammatory bowel disease [J]. United Eur Gastroenterol J, 2015, 3(5):A236-A237.
[22]
Pott F, Cichon C, Brückner M, et al. MicroRNA-320 as a biomarker to monitor the course of disease activity in experimental colitis as well as in patients with inflammatory bowel disease [J]. United Eur Gastroenterol J, 2(1):A214.
[23]
Ibrahim AF, Weirauch U, Thomas M, et al. MicroRNA replacement therapy for miR-145 and miR-33a is efficacious in a model of colon carcinoma [J]. Cancer Res, 2011, 71(15):5214-5224.
[24]
Lanford RE, Hildebrandt-Eriksen ES, Petri A, et al. Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection [J]. Science, 2010, 327(5962):198-201.
[25]
Wu F, Zikusoka M, Trindade A, et al. MicroRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2 alpha [J]. Gastroenterology, 2008, 135(5):1624-1635.
[26]
Simonson B, Das S. MicroRNA Therapeutics: the Next Magic Bullet? [J]. Mini Rev Med Chem, 2015, 15(6):467-474.
[27]
Viscido A, Bagnardi V, Sturniolo GC, et al. Survival and causes of death in Italian patients with ulcerative colitis. A GISC nationwide study [J]. Dig Liver Dis, 2001, 33(8):686-692.
[28]
Feagins L A, Souza R F, Spechler S J. Carcinogenesis in IBD: potential targets for the prevention of colorectal cancer [J]. Nat Rev Gastroenterol Hepatol, 2009, 6(5):297-305.
[29]
Ludwig K, Fassan M, Mescoli C, et al. PDCD4/miR-21 dysregulation in inflammatory bowel disease-associated carcinogenesis [J]. Virchows Arch, 2013, 462(1):57-63.
[30]
Ranjha R, Aggarwal S, Bopanna S, et al. Site-Specific MicroRNA Expression May Lead to Different Subtypes in Ulcerative Colitis [J]. PLoS One, 2015, 10(11):e142869.
[31]
Olaru AV, Selaru FM, Mori Y, et al. Dynamic changes in the expression of MicroRNA-31 during inflammatory bowel disease-associated neoplastic transformation [J]. Inflamm Bowel Dis, 2011, 17(1):221-231.
[32]
Olaru AV, Yamanaka S, Vazquez C, et al. MicroRNA-224 negatively regulates p21 expression during late neoplastic progression in inflammatory bowel disease [J]. Inflamm Bowel Dis, 2013, 19(3):471-480.
[33]
Kunte D, Savkovic S, Qi W, et al. MiR-34a as potential fecal biomarker Colitis-induced Colorectal cancer [J]. Inflammatory Bowel Dis, 2011, 17: S86-S87.
[1] 闫文, 谢兴文, 顾玉彪, 雷宁波, 马成, 于文霞, 高亚雄, 张磊. 微小RNA与全膝关节置换术后深静脉血栓的研究进展[J]. 中华关节外科杂志(电子版), 2023, 17(06): 842-846.
[2] 杨蕾, 肖东琼, 钟亦思. 口腔菌群与儿童常见非口腔性疾病的关系[J]. 中华妇幼临床医学杂志(电子版), 2021, 17(05): 510-515.
[3] 马伟强, 马斌林, 吴中语, 张莹. microRNA在三阴性乳腺癌进展中发挥的作用[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 111-114.
[4] 丁丰悦, 武宏春, 黄莹, 殷为民, 雷伟. miR-148/152家族调控内皮细胞糖酵解相关基因的表达分析[J]. 中华细胞与干细胞杂志(电子版), 2021, 11(06): 321-328.
[5] 欧苏文, 罗康佳, 管子龙, 黄睿. MicroRNAs调控结直肠癌干细胞的研究进展[J]. 中华结直肠疾病电子杂志, 2021, 10(03): 306-312.
[6] 郑薏, 彭雯雯, 钟月丽. MicroRNA-34a调控电针对缺血再灌注损伤大鼠反应性星形胶质细胞的影响[J]. 中华脑科疾病与康复杂志(电子版), 2023, 13(03): 135-141.
[7] 赵小玉, 李彦东, 吴昊, 范海, 吕明月, 沈宇晟, 盛成俊, 曾加, 吴徐超, 朱国华, 更·党木仁加甫. 外泌体miRNA在脑胶质瘤中的诊断、治疗和预后的研究进展[J]. 中华脑科疾病与康复杂志(电子版), 2021, 11(06): 370-374.
[8] 许鹏, 魏志. 第三空间内镜技术临床应用进展[J]. 中华消化病与影像杂志(电子版), 2022, 12(06): 373-376.
[9] 黄文鹏, 李莉明, 薛桐, 刘肖楠, 耿尚文, 刘晨晨, 高剑波. 消化系统和腹膜腔炎性肌纤维母细胞瘤的CT表现与病理对照[J]. 中华消化病与影像杂志(电子版), 2022, 12(03): 133-137.
[10] 王家圆, 王晓东. 消化系统恶性肿瘤相关肌少症的研究进展[J]. 中华临床医师杂志(电子版), 2023, 17(07): 823-827.
[11] 冯佳佳, 刘丹, 张广炜, 金丽霞. microRNA与脑动脉粥样硬化斑块破裂的研究新进展[J]. 中华临床医师杂志(电子版), 2022, 16(06): 601-604.
[12] 汪颖, 李沛霖, 李泉, 狄红梅, 高昶. 呼出气一氧化氮监测诊断幽门螺杆菌感染的有效性研究[J]. 中华胃肠内镜电子杂志, 2023, 10(01): 37-40.
[13] 李锡勇, 杨溯, 张雄杰, 李松风, 韩鹏飞. microRNA与老年性骨关节炎[J]. 中华老年病研究电子杂志, 2022, 09(03): 51-55.
[14] 马晓瑭, 李婵娣, 李嘉辉, 许小冰. 高表达microRNA-17的内皮祖细胞外泌体对糖尿病缺血性脑卒中的治疗作用[J]. 中华脑血管病杂志(电子版), 2022, 16(04): 263-274.
[15] 王孟杰, 冯嵩, 马文渊, 陈超, 靳峰. 外泌体及其携带的microRNA与脑卒中的研究进展[J]. 中华脑血管病杂志(电子版), 2021, 15(06): 418-421.
阅读次数
全文


摘要