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中华结直肠疾病电子杂志 ›› 2016, Vol. 05 ›› Issue (06) : 468 -474. doi: 10.3877/cma.j.issn.2095-3224.2016.06.003

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结直肠癌的免疫检查点阻断治疗
魏少忠1, 胡胜2,()   
  1. 1. 430071 武汉,湖北省肿瘤医院胃肠外科
    2. 湖北省肿瘤医院肿瘤内科
  • 收稿日期:2016-06-16 出版日期:2016-12-25
  • 通信作者: 胡胜

Immune checkpoints blocking treatment of colorectal cancer

Shaozhong Wei1, Sheng Hu2,()   

  1. 1. Department of Gastrointestinal Surgery, Hubei Cancer Hospital, Hubei Cancer Hospital, Wuhan 430071, China
    2. Department of Medical Oncology, Hubei Cancer Hospital, Wuhan 430071, China
  • Received:2016-06-16 Published:2016-12-25
  • Corresponding author: Sheng Hu
  • About author:
    Corresponding author: Hu Sheng, Email:
引用本文:

魏少忠, 胡胜. 结直肠癌的免疫检查点阻断治疗[J/OL]. 中华结直肠疾病电子杂志, 2016, 05(06): 468-474.

Shaozhong Wei, Sheng Hu. Immune checkpoints blocking treatment of colorectal cancer[J/OL]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2016, 05(06): 468-474.

结直肠癌是常见的恶性肿瘤之一,总体预后相对较差。对转移性结直肠癌患者而言,探索更有效的治疗方法显得尤为重要。免疫治疗,特别是免疫检查点抑制剂,是近几年研究的热点,在黑色素瘤、肺癌等疾病中取得了较好的疗效。本文将重点阐述抗肿瘤免疫在结直肠癌中的作用,以及各种免疫检查点抑制剂在结直肠癌中应用的最新进展。

Colorectal cancer is one of the most common malignacies, and the overall prognosis is not satisfying. For patients with metastatic colorectal cancer, there is an urgent need to explore new efficient treatment methods. Immunotherapy, especially immune checkpoint inhibitors, are the current research focuses, which show excellent outcomes in melanoma and lung cancer. This review will outline the antitumor immunity and the new progress of a variety of immune checkpoint inhibitors in colorectal cancer.

[1]
Oh DY,Venook AP,Fong L. On the Verge: Immunotherapy for colorectal carcinoma[J]. J Natl Compr Canc Netw, 2015, 13(8): 970-978.
[2]
Shankaran V,Ikeda H,Bruce AT, et al. IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity[J]. Nature, 2001, 410(6832): 1107-1111.
[3]
Pernot S,Terme M,Voron T, et al. Colorectal cancer and immunity: what we know and perspectives[J]. World J Gastroenterol, 2014, 20(14): 3738-3750.
[4]
Bystrom J,Taher TE,Muhyaddin MS, et al. Harnessing the Therapeutic Potential of Th17 Cells[J]. Mediators Inflamm, 2015, 2015: 205156.
[5]
Ge J,Zhu L,Zhou J, et al. Association between co-inhibitory molecule gene tagging single nucleotide polymorphisms and the risk of colorectal cancer in Chinese[J]. J Cancer Res Clin Oncol, 2015, 141(9): 1533-1544.
[6]
Mojtahedi Z,Mohmedi M,Rahimifar S, et al. Programmed death-1 gene polymorphism (PD-1.5 C/T) is associated with colon cancer[J]. Gene, 2012, 508(2): 229-232.
[7]
Topalian SL,Hodi FS,Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer[J]. N Engl J Med, 2012, 366(26): 2443-2454.
[8]
Brahmer JR,Drake CG,Wollner I, et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates[J]. J Clin Oncol, 2010, 28(19): 3167-3175.
[9]
Chung KY,Gore I,Fong L, et al. Phase II study of the anti-cytotoxic T-lymphocyte-associated antigen 4 monoclonal antibody, tremelimumab, in patients with refractory metastatic colorectal cancer[J]. J Clin Oncol, 2010, 28(21): 3485-3490.
[10]
Hu C,Anderson AC,Schubart A, et al. The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity[J]. Nat Immunol, 2005, 6(12): 1245-1252.
[11]
Chen J,Chen Z. The effect of immune microenvironment on the progression and prognosis of colorectal cancer[J]. Med Oncol, 2014, 31(8): 82.
[12]
CDX-1127 Program Update, November 2013 at SITC 2013,

URL    
[13]
Linch SN,McNamara MJ,Redmond WL. OX40 Agonists and Combination Immunotherapy: Putting the Pedal to the Metal[J]. Front Oncol, 2015, 5: 34.
[14]
Pedroza-Gonzalez A,Verhoef C,Ijzermans JN, et al. Activated tumor-infiltrating CD4regulatory T cells restrain antitumor immunity in patients with primary or metastatic liver cancer[J]. Hepatology, 2013, 57(1): 183-194.
[15]
Cepowicz D,Gryko M,Zareba K, et al. Assessment of activity of an adhesion molecule CD134 and CD137 in colorectal cancer patients[J]. Pol Przegl Chir, 2011, 83(12): 641-645.
[16]
Vonderheide RH,Burg JM,Mick R, et al. Phase I study of the CD40 agonist antibody CP-870, 893 combined with carboplatin and paclitaxel in patients with advanced solid tumors[J]. Oncoimmunology, 2013, 2(1): e23033.
[17]
Xiao Y,Freeman GJ. The microsatellite instable subset of colorectal cancer is a particularly good candidate for checkpoint blockade immunotherapy[J]. Cancer Discov, 2015, 5(1): 16-18.
[18]
Cooper ZA,Reuben A,Amaria RN, et al. Evidence of synergy with combined BRAF-targeted therapy and immune checkpoint blockade for metastatic melanoma[J]. Oncoimmunology, 2014, 3(9): e954956.
[19]
Singh PP,Sharma PK,Krishnan G, et al. Immune checkpoints and immunotherapy for colorectal cancer[J]. Gastroenterol Rep (Oxf), 2015, 3(4): 289-297.
[20]
Kroemer G,Galluzzi L,Zitvogel L, et al. Colorectal cancer: the first neoplasia found to be under immunosurveillance and the last one to respond to immunotherapy?[J]. Oncoimmunology, 2015, 4(7): e1058597.
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